Preleukemia
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Síndromes Mielodisplásicas: enfoque epidemiológico e clínico em serviço de referência de alta complexidade
As Síndromes Mielodisplásicas (SMD) caracterizam um grupo de doenças de ordem clonal hematopoética evidenciadas por estudos em todo o mundo. Estudos epidemiológicos que abordem as características sociodemográficas e clínicas, com abordagem da sobrevida e evolução leucêmica dos casos não são encontrados na literatura brasileira, o que requer inve
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/09/2011
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2. Estados pre-leucemicos na infancia : estudo clinico e hematologico
A retrospective evaluation of 18 pre-leukemia in children was made among 320 patients that were referred to the Pediatric Department at A.C.Camargo Hospital in São Paulo - between January 84- December 91 with previously diagnostic of leukemia to be confirmed. Lymphoblastic leukemia was confirmed in 227 patients and non lymphoblastic leukemia in 54. Among th
Publicado em: 1994
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3. Preleukemia
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4. Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.
A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-globin mRNA ratio, and was translated normally. No detectabl
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5. S1 nuclease analysis of alpha-globin gene expression in preleukemic patients with acquired hemoglobin H disease after transfer to mouse erythroleukemia cells.
The loss of alpha-globin gene transcriptional activity rarely occurs as an acquired abnormality during the evolution of myeloproliferative disease or preleukemia. To test whether the mutation responsible for the loss of alpha-globin gene expression (hemoglobin H disease) in these patients is linked with the alpha-globin genes on chromosome 16, we transferred
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6. Increased expression of p53 protein in human leukemia cells.
We examined synthesis of the cellular phosphoprotein p53 in fresh bone marrow or peripheral blood cells from normal donors and from patients with leukemia, preleukemia, or other hematopoietic disorders. Lysates of cells labeled with [35S]methionine were immunoprecipitated with monoclonal antibodies to p53, and the immunoprecipitates were analyzed by NaDodSO4
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7. Pancytopenia as a clonal disorder of a multipotent hematopoietic stem cell.
Hematopoiesis was investigated in a 14-yr-old girl who had a 2-yr history of stable asymptomatic pancytopenia and who was also heterozygous at the structural locus for glucose-6-phosphate dehydrogenase (G-6-PD). There was no morphologic or cytogenetic evidence for preleukemia and no suggestion of Fanconi anemia. In the skin and sheep erythrocytes-rosetted T
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8. Treatment of premalignancy: prevention of lymphoma in radiation leukemia virus-inoculated mice by cyclosporin A and immunotoxin.
Radiation leukemia virus (RadLV)-induced preleukemic (PL) latency is characterized by the appearance of virus-infected PL cells in the thymus. The survival of these PL cells is dependent upon autostimulation with interleukin 4 (IL-4). We have intervened prophylactically in RadLV-induced preleukemia by using cyclosporin-A (CSA), which inhibits IL-4 production
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9. A PMLRARα transgene initiates murine acute promyelocytic leukemia
The malignant cells of acute promyelocytic leukemia (APL) contain a reciprocal chromosomal translocation that fuses the promyelocytic leukemia gene (PML) with the retinoic acid receptor α gene (RARα). To test the hypothesis that the chimera PMLRARα plays a role in leukemogenesis, we expressed a PMLRARα cDNA in myeloid cells of transgenic mice. PMLRARα t
The National Academy of Sciences of the USA.
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10. Increased responses to lymphokines are correlated with preleukemia in mice inoculated with Moloney leukemia virus.
In various mouse strains, inoculation with Moloney leukemia virus results in the establishment of an acute viremia which in most cases is followed by the induction of leukemia. Also associated with the viremia is the development of a chronic cellular immune response detectable in vitro by the ability of viral proteins to induce splenic lymphocyte proliferati
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11. Chromosome 7 long arm deletion breakpoints in preleukemia: mapping by pulsed field gel electrophoresis.
Chromosome 7 long arm deletions (7q-) are recurring chromosome abnormalities in leukemic bone marrow cells. In four patients we have previously localized the breakpoints in band 7q22 between the erythropoietin (EPO) and plasminogen activator inhibitor type 1 (PLANH1) genes that map 3 cM apart. The pro alpha 2(I) collagen (COL1A2, in band 7q22) and T cell rec
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12. Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis.
Particles with the density and enzymatic activity characteristic of known oncornavirus have been previously described in bone marrow cells from patients with leukemia in relapse and in remission. We have confirmed these findings and studied two patients in whom preleukemia was among the diagnostic considerations. Following cultivation of bone marrow from the