Procoagulant Activity
Mostrando 1-12 de 175 artigos, teses e dissertações.
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1. Retraction notice for: “Risk factors for early-onset ventilator-associated pneumonia in aneurysmal subarachnoid hemorrhage patients” [Braz J Med Biol Res (2018) 51(7): e6830]
Due to its various structures in bio-compounds, snake venom is the indisputable result of evolutionary stages of molecules with an increasingly complex structure, high specificity, and of great importance for medicine because of their potential. The present study proposed an underpinning examination of venom composition from nine species of venomous snakes u
Braz J Med Biol Res. Publicado em: 2020-01
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2. Protein structure of the venom in nine species of snake: from bio-compounds to possible healing agents
Due to its various structures in bio-compounds, snake venom is the indisputable result of evolutionary stages of molecules with an increasingly complex structure, high specificity, and of great importance for medicine because of their potential. The present study proposed an underpinning examination of venom composition from nine species of venomous snakes u
Braz J Med Biol Res. Publicado em: 2020-01
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3. Thrombin generation assays for global evaluation of the hemostatic system: perspectives and limitations
Abstract The existing techniques to evaluate hemostasis in clinical laboratories are not sensitive enough to detect hypercoagulable and mild hypocoagulable states. Under different experimental conditions, the thrombin generation test may meet these requirements. This technique evaluates the overall balance between procoagulant and anticoagulant forces and ha
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
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4. Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva
Leishmania parasites expose phosphatidylserine (PS) on their surface, a process that has been associated with regulation of host's immune responses. In this study we demonstrate that PS exposure by metacyclic promastigotes of Leishmania amazonensis favours blood coagulation. L. amazonensis accelerates in vitro coagulation of human plasma. In addition, L. am
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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5. Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom
Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/05/2013
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6. The infection of microvascular endothelial cells with ExoU-producing Pseudomonas aeruginosa triggers the release of von Willebrand factor and platelet adhesion
An increased plasma concentration of von Willebrand factor (vWF) is detected in individuals with many infectious diseases and is accepted as a marker of endothelium activation and prothrombotic condition. To determine whether ExoU, a Pseudomonas aeruginosa cytotoxin with proinflammatory activity, enhances the release of vWF, microvascular endothelial cells w
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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7. CaracterizaÃÃo bioquÃmica da atividade prÃ-coagulante de proteases de fluidos laticÃferos / Biochemical characterization of procoagulant activity of proteases fluid latex
As proteases de lÃtex tÃm atraÃdo atenÃÃo devido à habilidade de exibir atividades semelhantes à trombina e à plasmina. Neste estudo, as proteÃnas do lÃtex das plantas Calotropis procera (CpPL), Cryptostegia grandiflora (CgPL) e Plumeria rubra (PrPL) foram avaliadas em termos destas atividades. Para tanto, as amostras foram investigadas quanto as s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2011
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8. Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts
Ticks are blood-feeding arthropods widely distributed in the world and vectors of several diseases. As haematophagy demands evasion strategies and repeatedly infested hosts develop protective immune responses, we investigated the mechanisms of the Rhipicephalus (Boophilus) microplus saliva anti-haemostatic activity and the possible relationship between the a
Publicado em: 2011
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9. Purification and partial characterization of a coagulant serine protease from the venom of the Iranian snake Agkistrodon halys
Agkistrodon halys is one of several dangerous snake species in Iran. Among the most important signs and symptoms in patients envenomated by this snake is disseminated intravascular coagulation. A thrombin-like enzyme, called AH143, was isolated from Agkistrodon halys venom by gel filtration on a Sephadex G-50 column, ion-exchange chromatography on a DEAE-Sep
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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10. Procoagulant properties of human MV3 melanoma cells
A correlation between cancer and prothrombotic states has long been described. More recently, a number of studies have focused on the procoagulant mechanisms exhibited by tumor cells. In the present study, we dissected the molecular mechanisms responsible for the procoagulant activity of MV3, a highly aggressive human melanoma cell line. It was observed that
Brazilian Journal of Medical and Biological Research. Publicado em: 11/01/2008
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11. Atividade pró-coagulante da toxina ExoU de Pseudomonas aeruginosa: efeito sobre a expressão do fator tissular em células epiteliais respiratórias / Procoagulant activity of Pseudomonas aeruginosa toxin ExoU: effect on the expression of tissue factor by airway epithelial cells
To evaluate the capacity of the P. aeruginosa toxin ExoU to induce the expression of tissue factor (TF) by epithelial respiratory cells from the BEAS-2B cell line, cells infected with the ExoU-producing PA103 bacterial strain were compared with cells infected with a mutant obtained by deletion of the exoU gene and with control non-infected cells in their i)
Publicado em: 2008
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12. Biochemical and biological properties of Lonomia obliqua bristle extract
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L.
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2006-04