Programmed Cellular Death
Mostrando 1-12 de 121 artigos, teses e dissertações.
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1. ADP-ribosylation: from molecular mechanisms to human disease
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribos
Genet. Mol. Biol.. Publicado em: 13/12/2019
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2. Influence of the Paracoccidioides brasiliensis14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells
The fungal strain Paracoccidioides brasiliensisremains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the molecules that participate in this process remained unknown. Thus, this study evaluated the contribution of two P. brasiliensismolecules, the 14-3-3 and glycoprotein of 43 kDa proteins, which had been p
Mem. Inst. Oswaldo Cruz. Publicado em: 02/06/2015
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3. Vias de sobrevivência e morte em queratinócitos submetidos ao estresse oxidativo e choque hiperosmótico / Survival and death signaling pathways in keratinocytes exposed to oxidative stress and hyperosmotic shock
The epidermis is constantly confronted with multiple environmental stressors. Changes in humidity or exposition to UV radiation affect the redox state and osmotic balance, modifying the physiological characteristics of the skin. In response to different stresses, epidermal keratinocytes can activate distinct signaling pathways and the balance between death a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2011
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4. Mecanismos envolvidos com a sobrevivência de Xylella fastidiosa em condições de estresse e efeito de N-Acetil-L-Cisteína em seu biofilme / Mechanisms involved in Xylella fastidiosa survival under stress conditions and effect of N-Acetyl-L-Cysteine on its biofilm
Xylella fastidiosa is a Gram-negative bacterium that causes several diseases in different plant species, including citrus variegated chlorosis (CVC) in sweet orange (Citrus sinensis L. Osbeck), whose economic damage is of millions of dollars annually. The symptoms development has been associated with the blockage of xylem vessels caused by bacterial biofilm
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2010
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5. Influência da depleção e suplementação mitocondrial no processo de apoptose embrionária / Influence of mitochondrial depletion and suplementation in embryonic apoptosis
Studies developed with bovine zygotes submitted to a decrease of about 50% of the mitochondrial content did not present a deleterious effect on in vitro embryonic development. This model was developed by the centrifugation of zygotes after in vitro fertilization (IVF), removal of the mitochondria enriched cytoplast fraction (MECF) and posterior introduction
Publicado em: 2010
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6. The role of HSP 60 in leucocytes cells of bovine placenta / O papel da HSP 60 nas células leucocitárias da placenta bovina
The maternal-fetal tolerance involves, besides the immune system, many peculiarities regarding the type of placenta and placentation. The bovine placenta is considered not invasive and, as consequence of a superficial implantation without endometrial invasion, it establishes itself as complex barrier that interposes between the maternal and fetal circulation
Publicado em: 2009
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7. Differential proteomics and physiological characterization of two clones of Coffea canephora under water deficit / Proteômica diferencial e caracterização fisiológica de dois clones de Coffea canephora sob déficit hídrico
Understanding the mechanisms by which plants respond to water stress is crucial to predict the climate change impacts on crop productivity and ecosystems. Plants have long- distance root-to-shoot signaling mechanisms that generate the orchestration of adaptive responses. Root system signaling, as well as shoot, is often considerate important in growth contro
Publicado em: 2008
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8. Envolvimento de sinais co-estimulatórios na progressão das doenças periodontais humanas / Differential expression of costimulatory molecules in human periodontal diseases
Negative co-stimulatory signals mediated via cell surface molecules such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1) play a critical role in down-modulation immune responses and maintaining peripheral tolerance. Both CTLA-4 and PD-1 are induced on activated T cells, and these are involved in the immunopathogenesis of
Publicado em: 2007
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9. Bloqueio da fosforilação oxidativa no cultivo de embriões bovinos / Oxidative phosphorylation blockage of bovine culture embryos
Although in vitro embryo production has been improved in the last 2 decades, about 60% of the oocytes do not reach the blastocyst stage and embryo quality is very variable when compared with in vivo produced embryo. This developmental block can be affected by inorganic ions, buffers, aminoacids and gaseous atmosphere composition. The knowledge that there inf
Publicado em: 2006
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10. Histology and Histochemistry of the Reproductive Tract of Melipona quadrifasciata anthidioides (Hymenoptera, Apidae) in Virgin and Physogastric Queens / Histologia e histoquímica do aparelho reprodutor de Melipona quadrifasciata anthidioides (Hymenoptera, Apidae) em rainhas virgens e copuladas
Due to the economic and ecological importance, and the extinction risk that Meliponini is experiencing, many works were developed in search of understanding of reproductive biology of these bees. The importance of the mating for ovaries development and oocytes maturation in insects has been investigated, but there are few research concerning the consequences
Publicado em: 2006
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11. Perfil de expressão genica de leucemias agudas por tecnica de microarranjo (microarrays) / Study of gene expression profile in acute leukemias by microarray assay
The development of gene expression assays, such as cDNA microarrays, has permitted the simultaneous study of several genes; one of this methods is the cDNA microarrays. These investigations contribute to the classification of diseases, comprehension of tumoral biology and, finally, the determination of genetically related prognostic factors. In this present
Publicado em: 2006
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12. Expressão espaço-temporal de marcadores de poliferação e morte celular na sinfise pubica de camundongo durante a prenhez, parto e pos-parto
Marked changes in mice pubic symphysis occurs by the end of pregnancy. Recently, we demonstrated that these changes in the pubic symphysis during the period under study are directly associated with extracellular matrix components remodeling mainly collagen, elastic fibers system, proteoglycans and glycosaminoglycans. Tissue remodeling involves a dynamic bala
Publicado em: 2005