Prolonged Release
Mostrando 1-12 de 443 artigos, teses e dissertações.
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1. Linseed Oil Nanoemulsion with Pluronic® F127 Loaded with Betulinic Acid: Preparation, Rheology, MTT Assay and in vitro Release Kinetics
The main objective of this work was to develop a nanoemulsion based on linseed oil and betulinic acid, stabilized with Pluronic F127 and polyglycerol polyricinoleate, for anticancer applications. The nanoemulsions were synthesized by ultrasound and evaluated for in vitro cytotoxicity, particle size, polydispersity index, zeta potential, morphology, encapsula
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Structural and Functional Stabilization of Sericin from Bombyx mori Cocoons in a Biopolysaccharide Film: Bioorigami for Skin Regeneration
Development and optimization of a bioorigami film with silk sericin was pursued for skin regeneration. Several formulations were produced, with varying integrated sericin contents, viz. 0, 1, 2, 5, 10, 20 and 50 mgsericin mLfilm-1. The physico-chemical characteristics of the bioorigami films produced were evaluated via infrared spectrophotometry, X-ray diffr
J. Braz. Chem. Soc.. Publicado em: 2020-04
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3. Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A mod
Braz. J. Pharm. Sci.. Publicado em: 15/08/2019
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4. Síntese e avaliação de nanopartículas de sílica mesoporosas na liberação controlada de feromônios repelentes de abelha
Resumo Neste estudo foi avaliado o armazenamento e liberação de feromônios repelentes de abelhas em uma nanoestrutura de sílica mesoporosa. O nanomaterial foi sintetizado via método sol-gel e caracterizado por microscopia eletrônica de transmissão, espectroscopia de infravermelho e método BET. As nanopartículas mesoporosas apresentaram-se com área
Cerâmica. Publicado em: 06/06/2019
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5. A New Phe-Free Protein Substitute Engineered to Allow a Physiological Absorption of Free Amino Acids for Phenylketonuria
Abstract An innovative technology (Physiomimic Technology) has been applied to amino acids (AAs) formulated for patients with phenylketonuria, with the objective of masking AA taste and odor and prolonging AA release in the gut, allowing a physiological absorption. This technology entails that the AAs are processed with functional additives that are able to
J. inborn errors metab. screen.. Publicado em: 28/02/2019
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6. Liposomes as potential carriers for ketorolac ophthalmic delivery: formulation and stability issues
ABSTRACT Drug delivery to treat ocular disorders locally is a challenging endeavor. Traditional ocular dosage form - eye drops - exhibits poor availability, consequently inefficient therapeutic response. The objective of the study was to formulate and characterize a ketorolac tromethamine ocular system with a prolonged release pattern based on liposomes as a
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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7. In vitro and in vivo evaluation of nano-based films for buccal delivery of zolpidem
Abstract Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially e
Braz. oral res.. Publicado em: 28/11/2016
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8. Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
Biodegradable nanoparticles (NPs) have received considerable attention because of their possible use in the development of strategies for the topical delivery of oils and therapeutic drugs, particularly when drug penetration in dermis is desired. Zein is a prolamine and is a promising material for the design of drug delivery systems. In this study, NPs were
Quím. Nova. Publicado em: 2014-06
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9. Marine-friendly antifouling coating based on the use of a fatty acid derivative as a pigment
This study was devoted to examining the application of copper dodecanoate as a non-contaminant antifouling pigment due to its low copper content and fatty acid nature. For this purpose, antifouling paints with mono-component epoxy resin and rosin matrixes were formulated, and their antifouling efficiency was evaluated. Before its incorporation into the diffe
Mat. Res.. Publicado em: 18/03/2014
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10. Cardiomyocyte dysfunction during the chronic phase of Chagas disease
Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type C
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-04
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11. Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation
No presente estudo foram preparadas microesferas de poli(hidroxibutirato-co-hidroxivalerato) (PHBV) e poli(ácido láctico) (PLA) com o objetivo de prolongar a liberação do ibuprofeno, utilizado como fármaco modelo. Empregou-se o método de emulsificação e evaporação do solvente óleo em água (O/A), variando-se a proporção entre os polímeros. Toda
Braz. J. Pharm. Sci.. Publicado em: 2012-12
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12. Development and characterization of PLGA nanocapsules of grandisin isolated from Virola surinamensis: in vitro release and cytotoxicity studies
The most studied phyto constituent isolated from Virola surinamensis (Rol. ex Rottb.) Warb., Myristicaceae, is the tetrahydrofuran neolignan grandisin, which exhibits a series of biological activities, including trypanocidal, larvicidal and antitumoral. Due to its extremely low solubility, additional studies, including in vivo investigations are challenged b
Rev. bras. farmacogn.. Publicado em: 06/11/2012