Propylthiouracil
Mostrando 1-12 de 70 artigos, teses e dissertações.
-
1. Adhesion molecules before and after propylthiouracil in patients with subclinical hyperthyroidism
RESUMO ANTECEDENTES O objetivo deste estudo foi investigar o efeito do tratamento com propiltiouracil nas moléculas de adesão em pacientes com hipertireoidismo subclínico. MÉTODOS Neste estudo, 168 pacientes diagnosticados com hipertireoidismo subclínico foram tratados com propiltiouracil por um ano. Os níveis de moléculas de adesão, especificame
Rev. Assoc. Med. Bras.. Publicado em: 2020-08
-
2. Antineutrophil cytoplasmic antibodies in patients treated with methimazole: a prospective Brazilian study
Resumo Introdução: Os efeitos adversos de drogas antitireoidianas são conhecidos. Vasculite associada a anticorpos anticitoplasma de neutrófilos é uma reação adversa grave. A maioria dos estudos que avaliam anticorpos anticitoplasma de neutrófilos relacionado a drogas antitireoidianas envolveu pacientes tratados com propiltiouracil, entretanto menos
Braz. j. otorhinolaryngol.. Publicado em: 07/11/2019
-
3. Propylthiouracil-induced agranulocytosis as a rare complication of antithyroid drugs in a patient with Graves’ disease
RESUMO INTRODUÇÃO: A doença de Graves (DG) é uma doença autoimune caracterizada por hipertireoidismo. As drogas antitireoidianas (DAT) são opções terapêuticas disponíveis. A agranulocitose é uma complicação rara, potencialmente fatal desta terapia. Neste estudo, relatamos um caso de agranulocitose induzida por propiltiouracil (PTU) em paciente
Rev. Assoc. Med. Bras.. Publicado em: 22/07/2019
-
4. Effect of Transient Treatment with Propylthiouracil on Some Reproduction Traits and Live Weight of Japanese Quails
ABSTRACT This study was conducted to investigate the effects of transient treatment with propylthiouracil (PTU) on some reproduction traits and live weight of quails. The trial lasted 8 weeks. To accomplish this goal, 700 1-day-old quail chicks were used, randomly divided into 8 groups. PTU was added to feed by 0.1% and 0.5% /wt. The first 4 groups had 0.5%
Rev. Bras. Cienc. Avic.. Publicado em: 2017-12
-
5. Risk of congenital anomalies associated with antithyroid treatment during pregnancy: a meta-analysis
To evaluate the association of either propylthiouracil or methimazole treatment for hyperthyroidism during pregnancy with congenital malformations, relevant studies were identified by searching Medline, PubMed, the Cochrane Library and EMBASE. We intended to include randomized controlled trials, but no such trials were identified. Thus, we included cohort
Clinics. Publicado em: 2015-06
-
6. Neonatal hyper- and hypothyroidism alter the myoglobin gene expression program in adulthood
Myoglobin acts as an oxygen store and a reactive oxygen species acceptor in muscles. We examined myoglobin mRNA in rat cardiac ventricle and skeletal muscles during the first 42 days of life and the impact of transient neonatal hypo- and hyperthyroidism on the myoglobin gene expression pattern. Cardiac ventricle and skeletal muscles of Wistar rats at 7-42 da
Braz J Med Biol Res. Publicado em: 24/06/2014
-
7. Determination of propylthiouracil in pharmaceuticals by differential pulse voltammetry using a cathodically pretreated boron-doped diamond electrode
Um procedimento simples é descrito para a determinação de propiltiouracil (PTU) por voltametria de pulso diferencial (DPV) usando um eletrodo de diamante dopado com boro (BDD) pré-tratado catodicamente. Estudos por voltametria cíclica indicam que a oxidação do PTU é irreversível a um potencial de pico de 1,42 V (vs. Ag/AgCl (KCl 3,0 mol L-1)) em uma
J. Braz. Chem. Soc.. Publicado em: 2013-09
-
8. Influência de processos antagônicos no desenvolvimento de sistema de análises em fluxo para a determinação espectrofotométrica de propiltiouracil em medicamentos
A multi-commuted flow system was developed to determine propylthiouracil (PTU) based on the reaction of its thiol form with iminoquinone radical generated by the oxidation of N,N-dimethyl-p-phenylenediamine in an alkaline medium. PTU can be found in tautomeric forms and the tautomeric equilibrium was displaced to enhance the thiol form. However, the reaction
Quím. Nova. Publicado em: 2013
-
9. Alternative complement pathway and factor B activities in rats with altered blood levels of thyroid hormone
Evaluating the activity of the complement system under conditions of altered thyroid hormone levels might help elucidate the role of complement in triggering autoimmune processes. Here, we investigated alternative pathway (AP) activity in male Wistar rats (180 ± 10 g) after altering their thyroid hormone levels by treatment with triiodothyronine (T3), propy
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
-
10. Influencia dos hormonios tireoidianos na densidade ossea e na periodontite : estudo em ratos / The influence of thyroid hormones on bone density and periodontitis : a study in rats
Thyroid hormones play a critical role on bone metabolism. However, data regarding the effect of thyroid hormones alterations on mandibular bone density and on the progression of periodontal disease are limited. The aim of the present study was to evaluate, in rats, the influence of different serum levels of thyroid hormones on: (1) the bone mineral density a
Publicado em: 2009
-
11. Influence of hipothyroidism on experimental melanoma progression / Influência do hipotireoidismo na progressão do melanoma experimental
Este trabalho teve por objetivo avaliar os efeitos do hipotireoidismo experimental induzido mediante utilização da droga propiltiouracil ou por tireoidectomia actínica, utilizando-se Iodo131, sobre o crescimento tumoral local e potencial metastático do melanoma murino, cepa B16F10 em camundongos C57BL6. O trabalho constituiu-se de dois experimentos disti
Publicado em: 2006
-
12. Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole
Nonobese diabetic (NOD) mice and a derived strain, NOD.H.2h4, have been used as a model for experimental spontaneous thyroiditis and thyroiditis induced by iodide excess after a goiter-inducing period. Some authors have proposed that iodide, given after methimazole or propylthiouracil, is capable of inducing apoptosis in thyroid cells and that anti-thyroid d
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-03