Pyrazinamide
Mostrando 1-12 de 145 artigos, teses e dissertações.
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1. Cutaneous tuberculosis: epidemiological, clinical, diagnostic and therapeutic update
Abstract Tuberculosis is certainly one of the diseases considered to be ancient on planet Earth. The etiological agent of tuberculosis is Mycobacterium tuberculosis. This terrible bacterial infection still results in severe socioeconomic consequences to date, and its complete eradication represents a great challenge. It constitutes one of the most important
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Aspectos clínicos e tratamento de pacientes com tuberculose ocular presumida em centro de referência de São Paulo, Brasil. Estudo retrospectivo
Resumo Objetivo: Descrever aspectos clínicos e esquema terapêutico dos pacientes com tuberculose ocular presumida tratados em um centro de referência em tuberculose de São Paulo. Métodos: Estudo retrospectivo descritivo. O teste exato de Fisher foi realizado quando apropriado. Resultados: A queixa mais comum foi baixa acuidade visual (83,1%), seguida
Rev. bras.oftalmol.. Publicado em: 02/12/2019
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3. Endometrial Tuberculosis: Hysteroscopic Findings of a Clinical Case
Resumo A tuberculose endometrial é um diagnóstico raro na pós-menopausa e podemimetizar um carcinoma. O presente artigo descreve o caso de uma paciente de 54 anos com perda de peso, dor abdominal e ascite. A ultrassonografia mostrou espessamento endometrial, e a histeroscopia por vídeo revelou uma cavidade uterina com formações que apresentavam aspecto
Rev. Bras. Ginecol. Obstet.. Publicado em: 22/07/2019
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4. Serum pyrazinamide concentrations in patients with pulmonary tuberculosis
J. bras. pneumol.. Publicado em: 18/04/2019
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5. A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control
Abstract Background: Background: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor pulmonary status and treatment progression. The present study aimed to apply a three-dimensional (3D) reconstruction method base
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 14/02/2019
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6. Studies on new substituted pyridazinones: synthesis and biological evaluation
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents. The title compounds were prepared by reacting 6-aryl-4,5-dihydro-(2H)-pyridazin-3-one (2a-e) with formaldehyde and secondary cyclic
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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7. Antitubercular Activity Increase in Labdane Diterpenes from Copaifera Oleoresin through Structural Modification
The labdane diterpenes copalic acid, 3β-acetoxy-copalic acid, 3β-hydroxy-copalic acid and ent-agathic acid were isolated from Copaifera langsdorffii oleoresin. These four compounds were submitted to structural modifications by reduction with hydrogen/palladium, esterification with diazomethane, esterification with methanol/sulfuric acid and conversion into
J. Braz. Chem. Soc.. Publicado em: 2017-06
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8. In vitro antimicrobial efficacy of a fixed-dose combination of RHZE against M. tuberculosis
ABSTRACT The use of drugs in fixed-dose combination (FDC) is now recommended by the World Health Organization (WHO) due to the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. FDC uses different drugs against tuberculosis (TB) in a single tablet for phase-intensive therapeutic intervention. This therapy aims to optimize treatment, to p
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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9. Cytotoxicity and Leishmanicidal Activity of Isoniazid-Derived Hydrazones and 2-Pyrazineformamide Thiosemicarbazones
The isoniazid-derived hydrazones 2-pyridinecarbaldehyde- (HPCIH), 2-acetylpyridine- (HAPIH), 2-benzoylpyridine- (HBPIH), 2-pyridineformamide- (HPAmIH) and 2-pyrazineformamide- (HPzAmIH) isonicotinoyl hydrazones, as well as the pyrazinamide-derived thiosemicarbazones 2-pyrazineformamide- (HPzAm4DH), N(4)-methyl-2-pyrazineformamide- (HPzAm4M), N(4)-ethyl-2-pyr
J. Braz. Chem. Soc.. Publicado em: 2016-04
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10. Cutaneous tuberculosis with nonreactive PPD skin test: a diagnostic challenge
The authors report a case of cutaneous tuberculosis in a 63-year-old female patient, who had an infiltrated, erythematous-ferruginous plaque of indurated aspect on her right leg and a nonreactive PPD skin test. Diagnosis was made by tissue culture and PCR of skin biopsy material. The treatment was p
An. Bras. Dermatol.. Publicado em: 2015-02
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11. A influência da piperina na biodisponibilidade de fármacos: uma abordagem molecular
Piperine is the major alkaloid of Piper nigrum Linn., used as a spice and in folk medicine. We present a molecular docking study supporting experimental data on the enhancement in bioavailability of propranolol, theophylline, phenytoin, nevirapine, nimesulide, pyrazinamide, carbamazepine, and spartein in the presence of piperine. The complex formed with pipe
Quím. Nova. Publicado em: 2014
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12. Multidrug-resistant tuberculosis
Despite the efforts made worldwide to reduce the number of cases of drug-susceptible tuberculosis, multidrug-resistant tuberculosis (MDR-TB) constitutes an important public health issue. Around 440,000 new cases of MDR-TB are estimated annually, although in 2008 only 7% of these (29,423 cases) were notified. The laboratory tests for diagnosing resistance may
Braz J Infect Dis. Publicado em: 2013-04