Quinazolines
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Synthesis of some new mono, bis-indolo[1, 2-c]quinazolines: evaluation of their antimicrobial studies
Uma estratégia conveniente em três etapas é proposta para a síntese de mono e bis-indolo[1,2-c] quinazolinas, a partir de 2-(2-aminofenil)indol e aril aldeídos. Os novos compostos sintetizados foram caracterizados por análise elementar, IV, ¹H RMN, 13C RMN, e espectrometria de massa. Todos os derivados foram testados para avaliação das suas atividad
Journal of the Brazilian Chemical Society. Publicado em: 2010
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2. Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
Uma série de compostos 6-arilbenzimidazo[1,2-c]quinazolina (11-20) foram sintetizados pela condensação do 2-(o-aminofenil)benzimidazol com diferentes arilaldeídos seguida pela ciclização oxidativa dos 2-o-arilidenoaminofenilbenzimidazol (1-10). Todos os produtos foram caracterizados por espectroscopia no infravermelho (IR), ressonância magnética nucl
Journal of the Brazilian Chemical Society. Publicado em: 2010
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3. Determinação da toxidade in vitro e vivo de compostos quinazolinicos e identificação do acido homovanilico por espectrometria de ressonancia magnetica nuclear de hidrogenio (1 ANTPOT. H) / In vivo and in vitro toxicity determination of quinazolinic compounds and identification of homovanilic acid by hydrogen (1 ANTPOT. H) nuclear magnetic resonance spectrometry
Este projeto tem a finalidade de analisar as características toxicológicas de novos compostos quinazolínicos, que foram sintetizados recentemente no Instituto de Química-UNICAMP. Uma série de derivados de 4-fenilamino quinazolinas foi sintetizada como potentes inibidores da proteína quinase e sua citotoxicidade foi demonstrada através de técnicas de
Publicado em: 2009
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4. Effects of DMA (Quinazoline Compound) on inflammatory process / O efeito do DMA (composto quinazolinico) sobre o processo inflamatorio
: Inflammation has a main role in several connective tissue diseases and is an important element of infectious disease physiopathology. Recently it has been linked to obesity, diabetes and cardiovascular diseases. Adenosine, among the various inflammatory process mediators, is a potent autocoid and its bioavailability is limited by catabolism to inosine by a
Publicado em: 2008
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5. Sintese e caracterização de novas quinazolinas polissubstituidas
The objective of the present work was to synthesize new polisubstituted quinazolines from new aminocarboxylic acids. The first synthetic route, using 3,4-diidroxybenzoic acid and 4-methylcatechol, did not lead to satisfactory results. Therefore, a new route was proposed from 6-nitropiperonal, bearing a different protecting group - methylenedioxy. This new ro
Publicado em: 2004
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6. Novel Chemical Class of pUL97 Protein Kinase-Specific Inhibitors with Strong Anticytomegaloviral Activity
Human cytomegalovirus (HCMV) is a major human pathogen frequently associated with life-threatening disease in immunosuppressed patients and newborns. The HCMV UL97-encoded protein kinase (pUL97) represents an important determinant of viral replication. Recent studies demonstrated that pUL97-specific kinase inhibitors are powerful tools for the control of HCM
American Society for Microbiology.
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7. In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs.
The potency of antimalarial dihydrofolate reductase inhibitors, alone and in synergistic combination with dihydropteroate synthetase inhibitors, against the Kenyan K39 strain of Plasmodium falciparum (pyrimethamine resistant) and against normal replicating human bone marrow cells in in vitro culture has been studied. Therapeutic indices and rank order of syn
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8. Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa
Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii. Unfortunately, point mutations in the DHFR gene can confer resistance to inhibitors specific to these pathogens. We have developed a rapid system for test
American Society for Microbiology.