Rat Airways
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. β-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea
β-Citronellol is an alcoholic monoterpene found in essential oils such Cymbopogon citratus (a plant with antihypertensive properties). β-Citronellol can act against pathogenic microorganisms that affect airways and, in virtue of the popular use of β-citronellol-enriched essential oils in aromatherapy, we assessed its pharmacologic effects on the contracti
Braz J Med Biol Res. Publicado em: 04/12/2015
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2. Assessment of the mechanics of a tissue-engineered rat trachea in an image-processing environment
OBJECTIVES:Despite the recent success regarding the transplantation of tissue-engineered airways, the mechanical properties of these grafts are not well understood. Mechanical assessment of a tissue-engineered airway graft before implantation may be used in the future as a predictor of function. The aim of this preliminary work was to develop a noninvasive i
Clinics. Publicado em: 2014-07
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3. Estado funcional de fagócitos após a exposição de ratos ao formaldeído: relevância para a inflamação alérgica pulmonar. / Functional status of phagocytes after rat formaldehyde exposure: relevance for allergic lung inflammation.
Formaldehyde (FA) is an ambiental pollutant generated in industry and by burning of tobacco, alcohol, gasoline and LPG. As an airways irritant agent, the exposure to it may affect the modulation of allergic lung inflammation (ALI) triggered by unrelated antigens. We studied the functional activity of lung phagocytes and bone marrow cells from male Wistar rat
Publicado em: 2008
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4. Pharmacological contribution to the genese of neurogenic inflammation in the rat airways evoked by two ambient pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ). / Contribuição farmacológica à gênese da inflamação neurogênica em vias aéreas de ratos frente a dois poluentes: Partículas eliminadas na exaustão do diesel (PED) e 1,2-naftoquinona (1,2-NQ).
Neste estudo efetuou-se uma análise comparativa da resposta inflamatória e estresse oxidativo produzido pela administração intratraqueal (i.tr.) das PED e/ou 1,2-NQ em vias aéreas de ratos. O efeito destes poluentes sobre a funcionabilidade dos macrófagos foi também avaliado. A injeção i.tr. das PED, numa dose incapaz de causar edema, promoveu efeit
Publicado em: 2007
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5. The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice
To determine the relative contributions of Ca2+ signaling and Ca2+ sensitivity to the contractility of airway smooth muscle cells (SMCs), we compared the contractile responses of mouse and rat airways with the lung slice technique. Airway contraction was measured by monitoring changes in airway lumen area with phase-contrast microscopy, whereas changes in in
American Physiological Society.
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6. Chronic colonization of rat airways with Pseudomonas aeruginosa.
Colonization of the airways of rats by Pseudomonas aeruginosa was established by treating the animals with hexamethylphosphoramide (HMPA) and inoculating with P. aeruginosa. Male Sprague-Dawley rats were given tap water (controls) or HMPA in the drinking water at 2 or 4 mg/ml. The ciliated cells of the airway epithelium were denuded, and microulcerative lesi
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7. Effects of topical capsaicin in seasonal allergic rhinitis.
BACKGROUND--Mucosal exudation (luminal entry) of bulk plasma is a key feature of airway defence and inflammation. In guinea pig and rat airways this response is readily produced by neurogenic irritants, notably capsaicin. Thus "neurogenic airway inflammation" has become an established concept. The present study examines whether capsaicin also produces mucosa
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8. Effects of nicotine on the human nasal mucosa.
BACKGROUND--Topical application of nicotine and stimulation of tachykinin containing sensory nerves have been shown to produce mucosal exudation of plasma and derangement of the epithelial lining in guinea pig and rat airways. If this occurred in man these effects might contribute to the pathogenesis of airway disease. This study, performed in healthy volunt
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9. Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources
Slow reacting substance(s) of anaphylaxis (SRS-A) was isolated from both human (lung) and rat sources and compared with three synthetic SRS-As of known structure—leukotrienes (LTs) C-1, C-2, and D. Reversed-phase liquid chromatography was used both as a final purification step and a means of comparison of biologically derived and synthetic substances. Two
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10. Morphometric studies on the structural development of the lung in Macaca fascicularis during fetal and postnatal life.
The structural development of the normal monkey lung (Macaca fascicularis) from 61 days of gestation to 14 days postnatal age has been described using quantitative morphometric techniques. The lung of the adult monkey has also been studied. The airway and arterial branching pattern has been traced using serial sections. The alveolar number and size have been
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11. New observations of rat airway epithelium: a quantitative and electron microscopic study.
Epithelial thickness, depth of the ciliary layer and concentration of cells has been estimated at 5 levels of the rat airway (3 extrapulmonary and 2 intrapulmonary) and the ultrastructure of the cells described. Extrapulmonary airways have a pseudostratified epithelium, intrapulmonary airways a simple one. The epithelium thins progressively from upper to low
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12. Airway-specific recruitment of T cells is reduced in a CD26-deficient F344 rat substrain
Asthma is a chronic inflammatory disease affecting the airways. Increased levels of T cells are found in the lungs after the induction of an allergic-like inflammation in rats, and flow cytometry studies have shown that these levels are reduced in CD26-deficient rats. However, the precise anatomical sites where these newly recruited T cells appear primarily
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