Renin Activity
Mostrando 1-12 de 289 artigos, teses e dissertações.
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1. Study of serum and urinary markers of the reninangiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA
ABSTRACT Introduction: The Renin-Angiotensin-Aldosterone System (RAAS) has been suggested as a possible marker of renal injury in chronic diseases. This study proposes to analyze the serum and urinary markers of the RAAS in myelomeningocele patients with renal function abnormalities detected on DMSA. Material and Methods: Seventeen patients followed in our
Int. braz j urol.. Publicado em: 2020-10
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2. Effects of Aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats
Abstract Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tiss
An. Acad. Bras. Ciênc.. Publicado em: 17/12/2018
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3. Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
Objectives Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordanc
Arch. Endocrinol. Metab.. Publicado em: 24/07/2015
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4. The chronic blockade of angiotensin I-converting enzyme eliminates the sex differences of serum cytokine levels of spontaneously hypertensive rats
Sex hormones modulate the action of both cytokines and the renin-angiotensin system. However, the effects of angiotensin I-converting enzyme (ACE) on the proinflammatory and anti-inflammatory cytokine levels in male and female spontaneously hypertensive rats (SHR) are unclear. We determined the relationship between ACE activity, cytokine levels and sex diffe
Braz J Med Biol Res. Publicado em: 01/02/2013
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5. Mechanisms of endothelial dysfunction in obesity-associated hypertension
Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-05
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6. Sobrecarga de sal durante a gestação: efeito sobre o sistema renina angiotensiva sistêmico e renal da prole adulta de ratos Wistar / Salt overload during perinatal life: effect on the systemic and local renin-angiotensin system in adult offspring Wistar rats
O aporte de nutrientes ingerido pela mãe durante a gestação e o transporte dos nutrientes da placenta para o feto são essenciais para o crescimento fetal. A sobrecarga de sódio durante a gestação tem demonstrado ser um dos fatores responsáveis pela hipertensão na vida adulta da prole. Um estudo anterior em nosso laboratório demonstrou que além do
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2011
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7. Nefropatia crônica por ciclosporina : papel do ácido úrico e do sistema renina angiotensina aldosterona como mediadores de disfunção endotelial, inflamação e vasculopatia / Cyclosporine nephropathy : effect of uric acid and the renin angiotensin aldosterone system as mediators of endothelial dysfunction, inflammation vasculopathy
Chronic allograft nephropathy is characterized by stripped tubular atrophy and interstitial fibrosis, in presence of arteriolar hyalinosis, resembling an ischemic pattern of chronic kidney disease. Chronic ischemia is associated with reduced glomerular filtration rate, and increase in serum uric acid levels. Cyclosporine per se also has a direct effect on tu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2011
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8. Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
The role of G-protein activation in cardiovascular disorders is well-known. G-protein β3 subunit (GNB3) C825T polymorphism is associated with increased intracellular signal transduction. We investigated the role of the variant in plasma sodium and potassium concentrations and association with hypertension. 345 healthy controls and 455 patients with essentia
Genetics and Molecular Biology. Publicado em: 28/10/2011
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9. Hypertensive effects of the iv administration of picomoles of ouabain
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09
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10. Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent manner
Angiotensin II (ANG II), the main effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and also vascular remodeling through induction of inflammatory genes. Matrix metalloproteinases (MMPs) are considered to be important inflammatory factors. Elucidation of ANG II signaling pathw
Braz J Med Biol Res. Publicado em: 2011-03
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11. An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect
INTRODUCTION AND OBJECTIVE: The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that the antithrombotic effect of angiotensin-(1-7) involves receptor Mas-mediated NO-release from platelets. Here, we describe an orall
Clinics. Publicado em: 2011
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12. Maternal undernutrition and the offspring kidney: from fetal to adult life
Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure to fetal glucocorticoid, alterations in the components of the renin-angiotensin system, apoptosis, and DNA methylation. A low-protein diet d
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11