Resistance To The Acridine Derivatives
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Estudo do potencial anticÃncer de novos derivados acridÃnicos sintÃticos em modelos experimentais in vitro. / Study of the potential of new anticancer synthetic acridine derivatives in experimental models in vitro.
Acridines are planar aromatic polycyclic molecules that have the ability to progress in nuclear DNA. Many of its representatives have antibacterial, antiparasitic and antitumor. This study evaluated the cytotoxic potential of 22 new acridine compounds in strains of human tumor cells. Among these, four compounds [5-(acridin-9-yl-methilene)-3-(4-methyl-benzyl)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/01/2010
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2. Involved molecular mechanism in the resistance to the derivatives of acridine and antimycotic tioconazol in Aspergillus nidulans / Mecanismo molecular envolvido na resistência aos derivados de acridina e ao antimicótico tioconazol em Aspergillus nidulans.
A humanidade tem aumentado drasticamente o uso de antibióticos, antifúngicos, inseticidas, herbicidas e agentes quimioterápicos para tratar infecções, câncer e obter ganho econômico com a produção agrícola e industrial. O repetido uso destas substâncias leva freqüentemente à sua ineficiência devido à seleção de organismos resistentes ou tole
Publicado em: 2002
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3. Prevention of the Emergence of Drug Resistance in Bacteria by Acridines, Phenothiazines, and Dibenzocycloheptenes
It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives acridine orange, a
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4. Antimalarial 9-Anilinoacridine Compounds Directed at Hematin
Antimalarial 9-anilinoacridines are potent inhibitors of parasite DNA topoisomerase II both in vitro and in situ. 3,6-Diamino substitution on the acridine ring greatly improves parasiticidal activity against Plasmodium falciparum by targeting DNA topoisomerase II. A series of 9-anilinoacridines were investigated for their abilities to inhibit β-hematin form
American Society for Microbiology.
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5. Genetic and Molecular Properties of an Infectious Antibiotic Resistance (R) Factor Isolated from Klebsiella
A Klebsiella strain of human origin that was resistant to ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, and tetracycline was found to have all of these resistances associated with a R factor and a satellite molecular species of deoxyribonucleic acid (DNA) with an average buoyant density of 1.710 in cesium chloride gradients. There was no ev
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6. Impaired Transduction of R213 and Its Recovery by a Homologous Resident R Factor
Transduction by Plkc of drug-resistance markers of the factor R213 was shown to occur at an exceptionally low frequency (at less than 10−8 of the input phage), and they could not be transduced by P22. When the recipient cells carried a homologous R factor derived from R213, markers were transduced by Plkc at a normal frequency (at about 10−5 to 10−6 of