Retamycin
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Análise da produção do antitumoral retamicina em cultivos contínuos de Streptomyces olindensis ICB20 utilizando planejamento fatorial. / Analysis of the production of the antitumor drug retamycin in continous cultures of Streptomyces olindensis ICB 20 using factorial desing.
The aim of this project was to study the production of retamycin in bench-top bioreactors by Streptomyces olindensis ICB20 in continuous cultures in order to evaluate the influence of the agitation rate (N=300, 500 or 700 rpm), the dissolved oxygen concentration (20%, 50% or 80%) and the specific growth rate (µ=0.05, 0.15 or 0.25 h-¹). A full factorial exp
Publicado em: 2008
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2. Estudo da produção do antibiótico antitumoral retamicina em biorreatores com células imobilizadas de Streptomyces olindensis ICB20. / Production of the antitumor antibiotic retamycin by immobilized cells of Streptomyces olindensis ICB20 in bioreactors.
The purpose of this study was to investigate the production of the antitumor antibiotic retamycin by immobilized cells of Streptomyces. olindensis ICB20 in bioreactors. Cells were immobilized by entrapment in Ca-alginate gel (3%) after being grown in Erlenmeyers (reactivation and pre-immobilization cultures). The average diameter of the Ca-alginate beads was
Publicado em: 2007
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3. Infuência de diferentes limitações nutricionais sobre a produção de retamicina por Streptomyces olindensis ICB20. / Influence of different nutrient limitation on retamycin production by Streptomyces olindesis ICB 20.
O objetivo do presente trabalho foi estudar o efeito de diferentes limitações nutricionais sobre a produção de retamicina por Streptomyces olindensis ICB20. Realizaram-se cultivos contínuos empregando meios limitados em carbono, nitrogênio ou fosfato, variando-se a vazão específica de alimentação entre 0,025 e 0,075 h -1 . A análise dos dados dos
Publicado em: 2006
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4. The effect of dissolved oxygen concentration control on cell growth and antibiotic retamycin production in Streptomyces olindensis So20 fermentations
Cell growth and retamycin production in Streptomyces olindensis So20 were studied at different dissolved oxygen levels during fermentation. The profiles for cell growth and retamycin production in an experiment with dissolved oxygen control at 5% air saturation during production were similar to those in an experiment without dissolved oxygen control. However
Brazilian Journal of Chemical Engineering. Publicado em: 2004-06
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5. Produção do antitumoral retamicina por Streptomyces olindensis em processos descontínuo alimentado e contínuo. / Retamycin production by Streptomyces olindensis in continuous and fed-batch cultivations.
The objective of the present work was to study retamycin production in fed-batch and continuous cultivations of Streptomyces olindensis So20, a mutant strain, in order to obtain high antibiotic concentrations and analyse microorganism morphology employing image analysis techniques. The fed-batch runs were performed in order to control the specific growth rat
Publicado em: 2003
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6. Applications of image analysis in the characterization of Streptomyces olindensis in submerged culture
The morphology of Streptomyces olindensis (producer of retamycin, an antitumor antibiotic) grown in submerged culture was assessed by image analysis. The morphology was differentiated into four classes: pellets, clumps (or entangled filaments), branched and unbranched free filaments. Four morphological parameters were initially considered (area, convex area,
Brazilian Journal of Microbiology. Publicado em: 2002-01