Saralasin
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. EFFECT OF ANGIOTENSIN II ON BOVINE OOCYTE NUCLEAR MATURATION MEDIATED BY PGE2 AND PGF2α / O EFEITO DA ANGIOTENSINA II NA MATURAÇÃO NUCLEAR DE OÓCITOS BOVINOS É MEDIADO PELAS PROSTAGLANDINAS E2 E F2α
Em mamíferos, é bem estabelecido que o reinício da meiose ocorre após o pico préovulatório de LH e resulta no rompimento da vesícula germinativa (RVG), iniciando a maturação do oócito. Entretanto, a via pela qual essa gonadotrofina atua não está completamente elucidada. Nosso grupo demonstrou que a angiotensina II (AngII) apresenta uma importante
Publicado em: 2008
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2. THE ROLE OF ANGIOTENSIN II ON EARLY MECHANISM OF BOVINE OVULATION VIA AT2 RECEPTOR SUBTYPE / ANGIOTENSINA II NO MECANISMO INICIAL DE OVULAÇÃO, ATRAVÉS DOS RECEPTORES AT2, EM BOVINOS
The aim of this work was to investigate the role of angiotensin II (Ang II) in the mechanism of ovulation in the bovine, using an in vivo model, through the injection of the Ang II receptor antagonists in mature follicles. The animals were pre-synchronized and when the follicles reached a minimum diameter of 12mm, they received the treatments and were challe
Publicado em: 2006
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3. The effect of saralasin in the chronically cannulated ewe in the early puerperium.
The effects of angiotensin II receptor blockade with saralasin ((sar1) (ala8) angiotensin II) have been studied 1-3 days post partum in seven ewes with indwelling vascular cannulae. Control experiments were performed 48 h later in five of the same ewes. The infusion of saralasin at 1, 2, 4 and 8 micrograms kg-1 min-1 resulted in an initial small pressor resp
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4. Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.
The roles of intrarenal angiotensin (A) and thromboxane (TX) in the vascular hypersensitivity to renal nerve stimulation (RNS) and paradoxical vasoconstriction to renal perfusion pressure (RPP) reduction in the autoregulatory range in 1 wk norepinephrine (NE)-induced acute renal failure (ARF) in rats were investigated. Renal blood flow (RBF) responses were d
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5. Endogenous Angiotensin Stimulation of Vasopressin in the Newborn Lamb
The effect of furosemide on plasma renin, vasopressin (AVP), and aldosterone concentrations was studied in 10 control and 6 nephrectomized lambs during the 1st 2 wk of life. In a separate study in 10 newborn lambs, 1-sarcosine-8-alanine-angiotensin II (saralasin acetate, 5 μg/kg per min) was infused alone for 40 min, after which furosemide 2 mg/kg i.v. was
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6. Renin-Angiotensin System Inhibition in Conscious Sodium-Depleted Dogs: EFFECTS ON SYSTEMIC AND CORONARY HEMODYNAMICS
The role of the renin-angiotensin system in the regulation of the systemic and coronary circulations during sodium depletion was studied in conscious normotensive dogs by i.v. administration of teprotide (0.5 mg/kg), an angiotensin-converting enzyme inhibitor, and saralasin (0.05-5 μg/kg per min), an angiotensin-receptor antagonist. Sodium depletion was pro
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7. Altered renin release and propranolol potentiation of vasodilatory drug hypotension.
Vasodilating antihypertensive drugs induce hypotension with reflex tachycardia, renin release, and fluid and electrolyte retention. Propranolol can impair this renin release. The studies described here were designed to determine the hemodynamic role of vasodilatory drug-induced renin release and inhibition thereof by propranolol in two animals models, the un
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8. The effects of frusemide, saralasin and hypotension on fetal plasma renin activity and on fetal renal function.
1. In eleven chronically catheterized fetal sheep aged 124-142 days, hypotension caused by infusion of sodium nitroprusside (1.6-3.3 mg/h) and competitive antagonism of angiotensin II by saralasin (3.3 mg/h) both caused a fall in fetal urine flow (P less than 0.02 and P less than 0.05, respectively), and in sodium excretion (P less than 0.05 and P less than
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9. Short-term saralasin blockade of renal hypertension in fetal lambs.
1. In the fetal lamb, suprarenal aortic blood flow reduction is known to lead to an upper body hypertension. The dependency of this hypertension on the renin-angiotensin system was investigated. 2. Intravenous infusions of saralasin or saline vehicle were begun before suprarenal aortic blood flow reduction and continued for 24 h. 3. In those fetuses receivin
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10. Inappropriate renin secretion and abnormal cardiovascular reflexes in coarctation of the aorta.
The response of the renin-angiotensin system to high and low sodium diets, to standing, and to saralasin infusion was assessed before and after surgical correction of aortic coarctation in a 27-year-old man. The cardiovascular responses to tests of autonomic function were measured. The heart rate responses to the Valsalva manoeuvre and standing were abnormal
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11. Abnormal Adrenal Responsiveness and Angiotensin II Dependency in High Renin Essential Hypertension
Adrenal responsiveness to angiotensin II (AII) and the diastolic blood pressure responses to saralasin were studied in 19 patients with high renin essential hypertension (HREH) on a 10-meq Na+/100 meq K+ diet. The increment in plasma renin activity (PRA) between supine and upright positions was used as an estimate of the acute stimulation of the adrenal glan
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12. Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules.
Numerous previous studies have proposed a role for angiotensin II (AII) in the renal regulation of salt balance. At least one nephron site, the proximal convoluted segment, has been implicated in this role. We used in vitro microperfusion of rabbit proximal convoluted tubules to further examine this question. To insure use of appropriate in vivo concentratio