Second Generation
Mostrando 1-12 de 1147 artigos, teses e dissertações.
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1. Long-term effects of antipsychotics on mortality in patients with schizophrenia: a systematic review and meta-analysis
Objective: To gather current evidence on the impact of antipsychotics on long-term mortality in patients with schizophrenia. Methods: We systematically searched for articles in Embase, PubMed, and PsycINFO reporting the long-term mortality (follow-up > 1 year) of patients with schizophrenia who were using any antipsychotics. We then conducted multiple meta-
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Clozapine prescription trends in Brazil in the last decade
Objective: Clozapine is a second-generation antipsychotic indicated for treatment-resistant schizophrenia. Studies in several countries have shown a low rate of clozapine use despite the fact that approximately 30% of schizophrenia cases are treatment-resistant. In Brazil, few studies have addressed the frequency and variety of antipsychotic use in individua
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit
Abstract Objective The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to
J. Pediatr. (Rio J.). Publicado em: 2021-06
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4. Voltammetric Generation and Kinetic Stability of Nitro Anion Radical from Nitrofurazone in Ionic Liquids
The nitrofurazone (NF) electrochemical reduction has been studied by cyclic voltammetry (CV) and square wave voltammetry (SWV) in non-aqueous medium using three different ionic liquids (IL): BMImTf2N, BMImBF4 and BMMImTf2N, having a carbon fiber microelectrode as working electrode. In all of them, two reversible cathodic peaks were recorded for NF. Under hig
J. Braz. Chem. Soc.. Publicado em: 2021-04
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5. Multifunctionality of βCD/Ofloxacin and HPβCD/Ofloxacin Complexes: Improvement of the Antimicrobial Activity and Apoptosis Induction on Lung Adenocarcinoma A549 Cells
The ofloxacin (OFLOX) is a second-generation synthetic antibiotic that can be classified as a multifunctional drug, but is a poorly soluble drug, which influences its efficiency. The inclusion complexes of OFLOX with β-cyclodextrin (βCD) or hydroxypropyl-β-cyclodextrin (HPβCD) can improve the chemical characteristics of the drug; however, studies showing
J. Braz. Chem. Soc.. Publicado em: 2020-12
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6. LA PNEUMATOLOGIE DE VATICAN II
SUMMARY The pneumatology of the Second Vatican Council was among the Questiones disputatae between Orthodox, Protestants and Catholics theologians after the Council. Now that this generation has faded, it is important to draw up a new balance sheet. To do this, it is not enough to count the number of occurrences of the term Holy Spirit in the conciliar text,
Perspect. Teol.. Publicado em: 2020-08
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7. Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
ABSTRACT Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independently of human leukocyte antigen (HLA), is composed by
Hematol., Transfus. Cell Ther.. Publicado em: 2020-06
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8. THE SUCCESS OF THE BRAZILIAN ALCOHOL PROGRAM (PROÁLCOOL) - A DECADE-BY-DECADE BRIEF HISTORY OF ETHANOL IN BRAZIL
ABSTRACT The National Alcohol Program (Proálcool) was a strategic policy of the Brazilian government to replace petroleum-based fuels with alcohol (ethanol). Based on the review, we can choose the 1960s as a start point for a leap in development. Over the 500 years of sugarcane history in Brazil, the crop enters the second decade of the 21st century with ex
Eng. Agríc.. Publicado em: 2020-04
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9. Foreign direct investment in developing economies A study on the productivity spillover effects in Latin America
Abstract Purpose The aim of this study was to investigate how the productivity spillover effects of foreign direct investment (FDI) in the Latin American economies are manifested. Specifically, the paper sought to identify the role of foreign presence and government intervention through an industrial policy on total factor productivity in Latin American cou
RAUSP Manag. J.. Publicado em: 2020-03
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10. INFLUÊNCIA DO IMPEDIMENTO ESTÉRICO DE LIGANTES ANCILARES EM COMPLEXOS A BASE DE Ru APLICADOS EM METÁTESES DO ÁLCOOL E ACETATO CINAMÍLICOS
Cinnamyl alcohol (AC) and cinnamyl acetate (ACM) were used as substrates in olefin metathesis reactions catalyzed by RuCl2(PCy3)2(=CHPh), first-generation Grubbs catalyst-G1, and RuCl2(PCy3)(H2IMes)(= CHPh), second-generation Grubbs catalyst-G2. The reactions occurred in the same reaction conditions for both substrates, 50 °C, for 24 h, in the proportions R
Quím. Nova. Publicado em: 2020-01
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11. Backcrosses in a segregating population of Passiflora mediated by morphoagronomic and resistance traits
ABSTRACT The present study aims to characterize the genetic diversity of Passiflora setacea, P. edulis, their hybrids, and first-backcross progenies, and to indicate promising recombinants for generation advancement in a breeding program for transferring resistance to cowpea aphid-borne mosaic virus (CABMV). Ninety-one genotypes were evaluated for 37 morphoa
Bragantia. Publicado em: 13/12/2019
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12. Genotype by environment interaction and adaptability of photoperiod-sensitive biomass sorghum hybrids
ABSTRACT Biomass sorghum is an alternative feedstock to cogenerate energy and produce second-generation ethanol. The aim of this study was to evaluate the Genotype by Environment Interaction (GEI) in biomass sorghum and to identify the hybrids that associate high adaptability and stability using the Toler nonlinear regression, the Genotypes plus Genotype by
Bragantia. Publicado em: 13/12/2019