Sildenafil
Mostrando 1-12 de 154 artigos, teses e dissertações.
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1. ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice
Sildenafil, a selective inhibitor of phosphodiesterase type 5, induces powerful protection against myocardial ischemia-reperfusion injury through activation of cGMP-dependent protein kinase (PKG). We further hypothesized that PKG-dependent activation of survival kinase ERK may play a causative role in sildenafil-induced cardioprotection via induction of endo
American Physiological Society.
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2. Effect of sildenafil in cavernous arteries of patients with erectile dysfunction
INTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction. The effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction has not been established yet. The objective of this study was to assess the effect of sildenafil citrate i
International braz j urol. Publicado em: 2003-08
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3. Preoperative subcutaneous sildenafil injection increases random flap survival in rats
Abstract Purpose: To investigate the effect of subcutaneous sildenafil on random flap survival. Methods: Fourteen Wistar rats, which were divided in to two groups, were used for this experimental study. Rats in the sildenafil group received subcutaneous sildenafil injections daily for seven days before flap elevation. At the end of the treatment period,
Acta Cir. Bras.. Publicado em: 2018-03
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4. Resposta pressórica de pacientes com miocardiopatia chagásica ante o uso do sildenafil
OBJETIVO: Verificar o efeito do sildenafil na pressão arterial (PA) e freqüência cardíaca (FC) de indivíduos portadores de miocardiopata chagásica (MCC) e de disfunção ventricular sistólica grave (FE<40%) submetidos à atividade física. MÉTODOS: Foram avaliados 12 homens com fração de ejeção<40% e MCC confirmada por sorologia. Foi realizado o
Arquivos Brasileiros de Cardiologia. Publicado em: 2007-03
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5. Effect of sildenafil citrate on the cardiovascular system
Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H -pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4 S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5. In la
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-09
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6. Resposta ao sildenafil em pacientes com disfunção erétil : estudo de marcadores genéticos e bioquímicos relacionados ao óxido nítrico = Response to sildenafil in patients with erectile dysfunction : study of genetic and biochemical markers related to nitric oxide / Response to sildenafil in patients with erectile dysfunction : study of genetic and biochemical markers related to nitric oxide
A disfunção erétil (DE) é uma doença que atinge milhões de homens em todo o mundo e tem sua prevalência aumentada com a idade. O tratamento via oral mais utilizado para pacientes com DE é o sildenafil, um inibidor de fosfodiesterase do tipo 5, que age aumentando níveis de monofosfato cíclico de guanosina, melhorando assim a função erétil. O óxi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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7. Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles
OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester (L-NAME). METHODS: Male Wistar rats were treated with L-NAME and/or sildenafil for eight weeks. The Langend
Clinics. Publicado em: 2011
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8. Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats
Since there is evidence that paradoxical sleep deprivation (PSD) elicits penile erection (PE) and ejaculation (EJ), and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined th
Brazilian Journal of Medical and Biological Research. Publicado em: 22/10/2007
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9. Sildenafil diminui a hiperreatividade de aneis isolados de traqueia de ratos e altera a expressão genica de proteínas Canonical transient receptor potential após desafio antigênico
Sildenafil (Viagra ®) is a selective inhibitor of cyclic guanosinamonofosfato (cGMP) a specific phosphodiesterase-5 (PDE5) useful in the treatment of erectile dysfunction and pulmonary arterial hypertension. The increase in intracellular cGMP levels caused by inhibition of PDE5 causes several cellular events such as airway smooth muscle relaxation and inhib
Repositório Institucional da Universidade Federal do Ceará (UFC). Publicado em: 2014
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10. Biochemical and functional studies of twenty sildenafil analogues in human platelets and in the rabbit corpus cavernosum and aorta / Estudos funcionais e bioquimicos de vinte analogos do sildenafil em plaquetas humanas, corpo cavernoso e aorta de coelho
Sildenafil, a cGMP-specific phosphodiesterase-5 (PDE5) inhibitor, is used for the treatment of erectile dysfunction. In the search for a potent and selective PDE5 inhibitor, new sildenafil analogues (6a-v), characterized by the presence on the sulphonyl group in the 5 position of novel N-4-substituted piperazines or ethylenediamine moiety, were synthesized.
Publicado em: 2008
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11. Avaliação do efeito gastroprotetor do Sildenafil (Viagra) na lesão gástrica induzida por álcool em ratos: papel do óxido nítrico, do GMPc e dos canais de potássio sensíveis ao ATP / Evaluation of the gastroprotetor effect of the Sildenafil (Viagra) in the induced gastric injury for alcohol in rats: paper of nitric oxide, the GMPc and the sensible potassium canals to the ATP
INTRODUÇÃO: Recentemente nós demonstramos que o sildenafil tem efeito protetor contra a lesão gástrica induzida por AINEs em ratos, através de uma diminuição na aderência de leucócitos e aumento do fluxo sanguíneo gástrico (Santos CL et al, BJP, 2005). O etanol induz lesão hemorrágica gástrica em ratos através de um aumento na produção de r
Publicado em: 2006
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12. Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate
PURPOSE: To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.METHODS: Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with s
Acta Cir. Bras.. Publicado em: 2014-04
