Smad7
Mostrando 1-12 de 77 artigos, teses e dissertações.
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1. Comparison of the effects of corneal and lacrimal gland denervation on the lacrimal functional unit of rats
RESUMO Objetivo: O nosso objetivo neste estudo foi comparar as alterações na unidade funcional lacrimal em dois modelos de síndrome do olho seco neurogênica: desnervação sensorial da córnea versus desnervação autonômica da glândula lacrimal. Métodos: A rede neural é um importante suporte para a unidade funcional lacrimal. Pode ser dividido em
Arquivos Brasileiros de Oftalmologia. Publicado em: 2022
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2. Hesperidin inhibits the epithelial to mesenchymal transition induced by transforming growth factor-β1 in A549 cells through Smad signaling in the cytoplasm
Hesperidin, a natural compound, suppresses the epithelial-to-mesenchymal transition through the TGF-β1/Smad signaling pathway. However, studies on the detailed effects and mechanisms of hesperidin are rare. The present study showed that, for A549 alveolar epithelial cells, the anti-proliferative effects of hesperidin occurred in a dose-dependent manner, wit
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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3. The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway
The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium verified with an uteroscope. In addition, 50 rats were rand
Braz J Med Biol Res. Publicado em: 07/10/2019
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4. Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage
Abstract Objectives: Infection, inflammation and bone resorption are closely related events in apical periodontitis development. Therefore, we sought to investigate the role of cyclooxygenase (COX) in osteoclastogenesis and bone metabolism signaling in periapical bone tissue after bacterial lipopolysaccharide (LPS) inoculation into root canals. Methodology
J. Appl. Oral Sci.. Publicado em: 03/06/2019
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5. Salvianolic acid A alleviates the renal damage in rats with chronic renal failure
Abstract Purpose: To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF). Methods: The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules
Acta Cir. Bras.. Publicado em: 28/02/2019
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6. Retinoic acid increases the effect of bone morphogenetic protein type 2 on osteogenic differentiation of human adipose-derived stem cells
Abstract Bone morphogenetic protein type 2 (BMP-2) and retinoic acid (RA) are osteoinductive factors that stimulate endogenous mechanisms of bone repair which can be applied on management of osseous defects in oral and maxillofacial fields. Objective Considering the different results of RA on osteogenesis and its possible use to substitute/potency BMP-2 ef
J. Appl. Oral Sci.. Publicado em: 21/02/2019
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7. Personalized Gene Expression Analyses of SMAD7 and KLF10 In Breast Cancer
Many cancer researchers use gene expression analysis for differentiation between tumor and normal cells for diagnostic, prognostic and therapeutic purposes. Most of studies compare either tumor cell lines by normal cell lines or tumor tissue of affected individuals by normal healthy control tissue. But expression of each special gene is unique in different i
Braz. arch. biol. technol.. Publicado em: 06/05/2016
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8. BMP-2 and titanium particles synergistically activate osteoclast formation
A previous study showed that BMP-2 (bone morphogenetic protein-2) and wear debris can separately support osteoclast formation induced by the receptor activator of NF-κB ligand (RANKL). However, the effect of BMP-2 on wear debris-induced osteoclast formation is unclear. In this study, we show that neither titanium particles nor BMP-2 can induce osteoclast fo
Braz J Med Biol Res. Publicado em: 2014-06
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9. Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES: This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs) in mediu
J. Appl. Oral Sci.. Publicado em: 2012-12
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10. Eventos moleculares associados ao aumento gengival induzido por ciclosporina A são atenuados pela superexpressão de Smad7 / Molecular events associated with cyclosporin A induced gingival overgrowth are attenuated by Smad 7 overexpression
O aumento gengival induzido por ciclosporina A (CsA) é causado por um acúmulo excessivo de matriz extracelular, resultado da ação do fator de crescimento transformante-beta 1 (TGF-ß1) sobre a atividade dos fibroblastos gengivais. O presente estudo investigou in vitro os efeitos da superexpressão de Smad7, um inibidor da sinalização de TGF-ß1, nos ev
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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11. Fator transformador de crescimento-β/Smad como via de sinalização em aortopatias
OBJETIVOS: Fator transformador de crescimento (TGF) -β/ Smad como via de sinalização em casos de dissecção aórtica e indivíduos normais não foi descrito anteriormente. O presente estudo foi elaborado para avaliar as expressões TGF-β/Smad como via de sinalização nos pacientes com dissecção aguda da aorta, em comparação com que nos pacientes co
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2011-09
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12. Transforming growth factor-β in graft vessels: histology and immunohistochemistry
OBJECTIVES: The biological functions of transforming growth factor-β signaling that involves Smad proteins have not been previously investigated with respect to coronary artery bypass grafts. The aim of the present study was to observe the immunostaining of proteins that are related to this signaling pathway. METHODS: Fifteen remnants of coronary artery byp
Clinics. Publicado em: 2011