Smooth Muscle Rat Aorta
Mostrando 1-12 de 66 artigos, teses e dissertações.
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1. Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta
ABSTRACT The objective of this study was to compare two alkaloids (antioquine and tetrandrine) with verapamil; knowing that the smooth muscle respond to KCl and relationships with calcium. The effects of antioquine and tetrandrine, was studied in adults Wistar rat with modified methods used in the determination of aorta contractility and compared with verapa
An. Acad. Bras. Ciênc.. Publicado em: 2018-04
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2. Effect of tobacco smoke on hydrogen sulfide-induced rat thoracic aorta relaxation
Levels of hydrogen sulfide (H2S), a gaseous signaling molecule, are reduced in the serum of individuals who smoke. We hypothesized that tobacco smoke influenced smooth muscle relaxation by decreasing H2S levels and this effect could also influence expression of cystathionine γ-lyase (CSE) and sulfonylurea receptor-2 (SUR-2). The aim of this study was to exp
Braz J Med Biol Res. Publicado em: 06/02/2017
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3. Sesquiterpene lactones from Hedyosmum brasiliense induce in vitro relaxation of rat aorta and corpus cavernosum
Abstract Hedyosmum brasiliense Miq., Chloranthaceae, has been used in Southern Brazil as a sedative, anti-inflammatory, and aphrodisiac. In this study, endothelium-intact and endothelium-denuded rat aortic rings and strips of corpus cavernosum were used to investigate the relaxant effects of an hexane fraction of leaves of H. brasiliense and its sesquiterpen
Rev. bras. farmacogn.. Publicado em: 2016-06
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4. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain
O-GlcNAcylation is a modification that alters the function of numerous proteins. We hypothesized that augmented O-GlcNAcylation levels enhance myosin light chain kinase (MLCK) and reduce myosin light chain phosphatase (MLCP) activity, leading to increased vascular contractile responsiveness. The vascular responses were measured by isometric force displacemen
Braz J Med Biol Res. Publicado em: 15/08/2014
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5. The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line
The success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia. The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neo-intimal hyperplasia, and a role for angiotensin II in vascular smooth muscle cell proliferation has been propos
Brazilian Archives of Biology and Technology. Publicado em: 2012-04
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6. MECANISMO DE AÇÃO DO VASORRELAXAMENTO INDUZIDO PELO ÓLEO ESSENCIAL DO Croton argyrophylloides EM AORTA DE RATO / MECHANISM OF ACTION OF VASORRELAXAMENTO INDUCED BY THE ESSENTIAL OIL Croton argyrophylloides IN RAT AORTA
O Croton argyrophylloides é uma planta nativa do Nordeste brasileiro aonde é popularmente chamada de marmemeiro prateado devido à coloração de suas folhas. O óleo essencial do Croton argyrophylloides (OECa) apresentou dois interessantes efeitos farmacológicos: ele foi capaz de relaxar o músculo liso vascular e possui uma elevada DL50. O objetivo prin
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/03/2011
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7. Avaliação das funções erétil e vascular de ratos com inflamação pulmonar decorrente da exposição ao material particulado ambiental liberado na exaustão do diesel. / Evaluation of erectile and vascular functions in rat with lung inflammation evoked by exposure to diesel exhaust particles.
Este estudo se propôs a avaliar o potencial inflamatório das partículas eliminadas na exaustão do diesel (PED) e 1,2-naftoquinona (1,2-NQ) sobre outros compartimentos, como o músculo liso vascular (aorta torácica; RTA) e do corpo cavernoso isolados de ratos (RCC) e os mecanismos envolvidos via ensaios funcionais e bioquímicos. A injeção i.tr. das PE
Publicado em: 2010
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8. Participação Do Cálcio Citosólico Sobre A Ação Espasmolítica Do Ácido Ent-7a-Acetoxitraquiloban-18-Óico E De Seu Derivado Hidroxilado Em Íleo Isolado De Cobaia / Partipation of cytosolic calcium in spasmolytic action of ent-7a-acetoxytrachyloban-18-oic acid and its hidroxylated derivated on guinea-pig ileum
From the stem bark of Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae), popularly known as pimenteria da terra, was isolated the diterpene ent-7-α-acetoxytrachyloban-18-oic acid (trachylobane-360) from which it was made a structural modification in which the acetoxy group was substituted by hydroxy generating the ent-7a-hidroxitrachyloban-18-oic aci
Publicado em: 2010
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9. Structural properties of lipid reconstructs and lipid composition of normotensive and hypertensive rat vascular smooth muscle cell membranes
Multiple cell membrane alterations have been reported to be the cause of various forms of hypertension. The present study focuses on the lipid portion of the membranes, characterizing the microviscosity of membranes reconstituted with lipids extracted from the aorta and mesenteric arteries of spontaneously hypertensive (SHR) and normotensive control rat stra
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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10. Investigação do efeito vasorelaxante e caracterização eletrofisiológica dos alcalóides curina e reticulina
It was been demonstrated that curine and reticuline, induced a vasodilator effect in the rat small mesenteric arteries through inhibition of voltage-gated Ca2+ channels (VGCC). These compounds, curine and reticuline were isolated from the root barks of Chondrondendron platyphyllum and Ocotea duckei Vattimo, respectively, therefore the aim of this work was to
Publicado em: 2009
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11. Efeitos celulares do óxido nítrico em aorta de ratos hipertensos renais / Cellular effects of the nitric oxide in rat aorta from renal hypertensive rats
O relaxamento vascular induzido pelo óxido nítrico (NO) está prejudicado em aorta de ratos hipertensos renais (2R-1C). A nossa hipótese é de que o menor efeito do NO na aorta de ratos 2R-1C pode estar relacionada com a maior degradação do NO e/ou modificação das cavéolas no músculo liso vascular (MLV), considerando que o NO pode ser degradado rapi
Publicado em: 2008
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12. Effects of a- and b-neurotoxins from Tityus serrulatus scorpion venom on catecholamines release, arterial blood pressure, neurotransmitters uptake and calcium concentration in smooth muscle cells from rat aorta / Efeitos de a e b-neurotoxinas da peçonha do escorpião Tityus serrulatus sobre a liberação de catecolaminas, pressão arterial, captação de neurotransmissores e concentração de cálcio em células de músculo liso de aorta de ratos
Toxinas que atuam em canais para Na+ operados por voltagem são as principais responsáveis pelos efeitos tóxicos do envenenamento escorpiônico e podem ser divididas em duas classes: a- e b-neurotoxinas. TsTX-V e TsTX-I da peçonha de Tityus serrulatus (TsV) são, respectivamente, exemplos destas toxinas. Neste trabalho, foram avaliados os efeitos da TsV e
Publicado em: 2006