Stereoselective Analysis
Mostrando 1-12 de 24 artigos, teses e dissertações.
-
1. Coupling DLLME-CE for the Stereoselective Analysis of Venlafaxine and Its Main Metabolites after Biotransformation by Fungi
Fungal biotransformations have become very important in the study of chiral drugs because the reactions performed by these microorganisms may be enantioselective. However, analyses of analytes present in liquid culture medium have proved to be very difficult due to the complexity of this matrix. The aim of this work was to couple dispersive liquid-liquid mic
J. Braz. Chem. Soc.. Publicado em: 2015-09
-
2. Evaluation of microbiological and biomimetic models in stereoselective metabolism of risperidone by high-performance liquid chromatography / Avaliação de modelos microbiológicos e modelos biomiméticos no metabolismo estereosseletivo da risperidona por cromatografia líquida de alta eficiência
Risperidone is an atypical antipsychotic drug. Its metabolism yields in two hydroxylated chiral metabolites, 7-hydroxyrisperidone (7-RispOH) and 9-hydroxyrisperidone (9-RispOH). The 9-RispOH metabolite presents the same pharmacologic activity of the parent drug risperidone. This led this drug to be marketed as drug under the generic name paliperidone. Studie
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
-
3. Microextraction techniques applied to the stereoselective analysis of ibuprofen, hydroxychloroquine and their metabolites in human urine. / Técnicas de microextração aplicadas à análise estereosseletiva do ibuprofeno, da hidroxicloroquina e de seus metabólitos em urina
The stereoselective analysis has been standing out in several areas, and it is mainly present in the pharmaceutical industry, since many drugs are marketed as racemic mixtures. The stereoselective analysis employing high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) is very useful for the determination of enantiomers at very low
Publicado em: 2007
-
4. Análise estereosseletiva da tioridazina e seus principais metabólitos: um estudo cinético de biotransformação empregando fungos / Stereoselective analysis of thioridazine and its major metabolites: a kinetic study of biotransformation by fungi
BORGES, K. B. Stereoselective analysis of thioridazine and its major metabolites: a kinetic study of biotransformation by fungi. 2006. 124p. Dissertation (Masters degree) Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, 2006. The interest in stereoselective biotransformation of drugs including the processe
Publicado em: 2006
-
5. Separação enantiomérica de fármacos em medicamentos por cromatografia líquida com fase estacionária quiral / Direct enantiomeric separation of drugs in pharmaceutical by high performance liquid chromatography with chiral stationary phase
The majority of the therapeutic agents, frequently prescribed, are formulated and commercialized as racemic mixture, even so for some of them, it has been demonstrated that the pharmacological and/or toxic effect are confined only to one of the enantiomer. Besides, it is well known that the enantiomers can present different pharmacokinetic and pharmacodynami
Publicado em: 2002
-
6. Adição diastereosseletiva de nucleofilos de carbono a ions N-aciliminios ciclicos: Aplicação na síntese de sistemas pirrolizidínico e indolizidínico monosubstituidos
Good diastereoeselection was observed in the addition of the carbon nucleophiles derived from S-tert-butyl thiopropionate 84, S-phenyl thiopropionate 96 and tert-butyl propionate 95 to the 6-membered N-acyliminium ion derived from 2-ethoxy carbamate 80. The 2RS, 1 SR relative stereochemistry of the major isomer formed in the addition of O-silylketeneacetal d
Publicado em: 1998
-
7. "Sintese diastereosseletiva de - lactonas identificação da configuração relativa do feromonio de formigas da especieCalomyrmex sp"
3,5,6- Trimelhyltetrahydro-pyran-2H-one (1) isolated and identified as the mayor component of the mandibular gland hom males of an Australian ant of the genus Calomymex. This lactone is presumed to function as a sex pheromone. In order to establish the relative stereochemistry, the four pos- sible racemates of this pheromone component were prepared. d-lacton
Publicado em: 1995
-
8. Sintese total e estereosseletiva do (+-)-invictolideo. Componente do feromonio de reconhecimento da formiga Solenopsis invicta
Invictolide (1), a component of the queen recognition pheromone of Solenopsis invicta (imported fire ant) has been synthesized through three different routes, the relative stereochemistry at C(5), C(6) and C(1 ) being established using stereoselective aldols condensations (Scheme LXVIII). Route A required eight steps (24% overall yield) starting with the add
Publicado em: 1991
-
9. Stereochemical Configuration of 4-Hydroxy-2-nonenal-Cysteine Adducts and Their Stereoselective Formation in a Redox-regulated Protein*
4-Hydroxy-2-nonenal (HNE), a major racemic product of lipid peroxidation, preferentially reacts with cysteine residues to form a stable HNE-cysteine Michael addition adduct possessing three chiral centers. Here, to gain more insight into sulfhydryl modification by HNE, we characterized the stereochemical configuration of the HNE-cysteine adducts and investig
American Society for Biochemistry and Molecular Biology.
-
10. Regio- and Stereoselective Metabolism of 7,12-Dimethylbenz[a]anthracene by Mycobacterium vanbaalenii PYR-1
The degradation of 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogenic polycyclic aromatic hydrocarbon, by cultures of Mycobacterium vanbaalenii PYR-1 was studied. When M. vanbaalenii PYR-1 was grown in the presence of DMBA for 136 h, high-pressure liquid chromatography (HPLC) analysis showed the presence of four ethyl acetate-extractable compounds and unu
American Society for Microbiology.
-
11. Toward the synthesis of the carbacylic ansa antibiotic kendomycin
The convergent synthesis of a benzofuran analog of the carbacyclic ansa compound kendomycin has been achieved by assembling three major fragments by means of epoxide opening and directed ortho lithiation. The crucial tetrahydropyran ring was formed by a highly stereoselective cationic cyclization. Analysis of all synthesized tetrahydropyran-arene compounds r
National Academy of Sciences.
-
12. Selective oxidation of carbolide C–H bonds by an engineered macrolide P450 mono-oxygenase
Regio- and stereoselective oxidation of an unactivated C–H bond remains a central challenge in organic chemistry. Considerable effort has been devoted to identifying transition metal complexes, biological catalysts, or simplified mimics, but limited success has been achieved. Cytochrome P450 mono-oxygenases are involved in diverse types of regio- and stere
National Academy of Sciences.