Sterol Demethylation Inhibitors
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Sensibilidade a fungicidas e adaptabilidade de Lasiodiplodia theobromae patogênico ao mamão
Application of fungicide is the main measure of management to stem-end rot and there is no information on the sensitivity and on the fitness costs arising from the reduction in sensitivity of its causal agent, Lasiodiplodia theobromae. One hundred and twenty monosporic isolates collected in producing areas of the Northeast region of Brazil, were divided into
Publicado em: 2009
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2. Induction and Characterization of Penicillium caseicolum Mutants Resistant to Ergosterol Biosynthesis Inhibitors
The isolation of Penicillium caseicolum mutants resistant to different fungicides which inhibit ergosterol biosynthesis is reported. Mutational frequencies for resistance were high (3 × 10−3 to 3 × 10−5). The levels of resistance toward the inhibitors of sterol C-14 demethylation were always low (<10), whereas high values were obtained with mutants res
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3. Characterization and catalytic properties of the sterol 14α-demethylase from Mycobacterium tuberculosis
Sterol 14α-demethylase encoded by CYP51 is a mixed-function oxidase involved in sterol synthesis in eukaryotic organisms. Completion of the Mycobacterium tuberculosis genome project revealed that a protein having homology to mammalian 14α-demethylases might be present in this bacterium. Using genomic DNA from mycobacterial strain H37Rv, we have established
The National Academy of Sciences.
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4. Tandem Repeat of a Transcriptional Enhancer Upstream of the Sterol 14α-Demethylase Gene (CYP51) in Penicillium digitatum
We investigated the mechanism of resistance to demethylation inhibitors (DMI) in Penicillium digitatum by isolating the CYP51 gene, which encodes the target enzyme (P45014DM) of DMI, from three DMI-resistant and three DMI-sensitive strains. The structural genes of all six strains were identical, but in the promoter region, a unique 126-bp sequence was tandem
American Society for Microbiology.
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5. Bcmfs1, a Novel Major Facilitator Superfamily Transporter from Botrytis cinerea, Provides Tolerance towards the Natural Toxic Compounds Camptothecin and Cercosporin and towards Fungicides
Bcmfs1, a novel major facilitator superfamily gene from Botrytis cinerea, was cloned, and replacement and overexpression mutants were constructed to study its function. Replacement mutants showed increased sensitivity to the natural toxic compounds camptothecin and cercosporin, produced by the plant Camptotheca acuminata and the plant pathogenic fungus Cerco
American Society for Microbiology.