Substantia Nigra Pars Compacta
Mostrando 1-12 de 51 artigos, teses e dissertações.
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1. Reinforcement omission effects in rats with bilateral lesions in the substantia nigra pars compacta and ventral tegmental area
Reinforcement omission effects (ROEs) are characterized by higher response rates after reinforcement omission than after reinforcement delivery. This pattern of behavior is interpreted in terms of motivational and attentional processes. Recent studies from our laboratory have shown that the amygdala, nucleus accumbens, and medial prefrontal cortex are involv
Braz J Med Biol Res. Publicado em: 10/07/2019
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2. Antioxidant Activity of Oral Administration of Rosmarinus Officinalis Leaves Extract on Rat's Hippocampus which Exposed to 6-Hydroxydopamine
Carnosic acid, a diterpene of Rosemarinus officinalis leaves extract (RE), has potent antioxidant activity in vitro. The dopaminergic connection of substantia nigra pars compacta to the hippocampus might be affected by oxidative stress which caused cognitive impairment observed in the early phase of Parkinson's disease (PD). Adult male Wistar rats were lesio
Braz. arch. biol. technol.. Publicado em: 29/04/2016
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3. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat
PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using
Acta Cir. Bras.. Publicado em: 2016-02
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4. Neuroinflamação na patofisiologia da doença de Parkinson e evidências terapêuticas de drogas antiinflamatórias
A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais comum afetando aproximadamente 1,6% da população acima de 60 anos de idade. Os sinais motores cardinais são o resultado da degeneração progressiva de neurônios dopaminérgicos da substantia nigra pars compacta (SNpc), a qual está intimamente envolvida com o controle motor. Atualme
Arq. Neuro-Psiquiatr.. Publicado em: 2015-07
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5. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl- D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 μg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal
Publicado em: 2011
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6. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl-D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 mg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal fl
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
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7. Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5
Brazilian Journal of Medical and Biological Research. Publicado em: 30/09/2008
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8. Envolvimento do sistema purinérgico, lactato e glicose em insultos do sistema nervoso central
O ATP pode influenciar diversos processos fisiológicos através dos receptores P1 e P2, controlando as concentrações de ATP e adenosina extracelulares. O ATP pode modular a liberação e/ou ligação de outros neurotransmissores. No SNC, a adenosina e guanosina atuam como importantes neuromoduladores com efeitos inibitórios sobre a atividade neuronal. A
Publicado em: 2008
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9. RepercussÃes da deficiÃncia crÃnica em Ãcidos graxos essenciais sobre a distribuiÃÃo e diferenciaÃÃo de neurÃnios dopaminÃrgicos da substÃncia negra
Ãcidos graxos essenciais (AGEs) sÃo fundamentais para o desenvolvimento normal do cÃrebro especialmente durante a gestaÃÃo e o aleitamento e de significÃncia para a neurogÃnese, diferenciaÃÃo neuronal e sinaptogÃnese, podendo exercer atividades antioxidativas e antiinflamatÃrias. No presente estudo investigamos se deficiÃncia crÃnica em Ãcido l
Publicado em: 2008
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10. Neuroprotective effect of ketamine/xylazine on two rat models of Parkinson's disease
There is a great concern in the literature for the development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic drugs have hyperpolarizing properties, they can possibly act as neuroprotectants. In the present study, we have investigated the neuroprotective effect of a mixture of ketamine (85 mg/kg) and xylazine (3 mg/kg) (K/X) on the 1
Brazilian Journal of Medical and Biological Research. Publicado em: 13/12/2006
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11. Atypical dopa responsive parkinsonism in a patient with megalencephaly, midbrain Lewy body disease, and some pathological features of Hallervorden-Spatz disease.
A 38 year old patient with megalencephaly, mental retardation, and lifelong tremor developed levodopa responsive parkinsonism in his mid-30s followed by the appearance of dyskinesiae, motor fluctuations, hallucinations, and dementia. Brain MRI showed, as well as other changes, iron deposition in the globus pallidus, substantia nigra, and the pulvinar of the
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12. Efferent connexions of the pars lateralis of the substantia nigra (SNL).
Unilateral lesions were made in the lateral nucleus of the substantia nigra in eight cats and in the zona compacta and reticularis in two cats. After a 10 days survival period, brains were perfused and stored in 10% formalin. Frozen sections were stained with the De Olmos-Ingram and Fink-Heimer silver methods for degenerating axons and terminals. Efferents f