Synaptic Activation
Mostrando 1-12 de 515 artigos, teses e dissertações.
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1. New frontiers in the study of memory mechanisms
We review recent work on three major lines of memory research: a) the possible role of the protein kinase M-zeta (PKMzeta) in memory persistence; b) the processes of “synaptic tagging and capture” in memory formation; c) the modulation of extinction learning, widely used in the psychotherapy of fear memories under the name of “exposure therapy”. PKMz
Rev. Bras. Psiquiatr.. Publicado em: 2013-06
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2. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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3. NAA and NAAG variation in neuronal activation during visual stimulation
N-acetyl-aspartyl-glutamate (NAAG) and its hydrolysis product N-acetyl-L-aspartate (NAA) are among the most important brain metabolites. NAA is a marker of neuron integrity and viability, while NAAG modulates glutamate release and may have a role in neuroprotection and synaptic plasticity. Investigating on a quantitative basis the role of these metabolites i
Braz J Med Biol Res. Publicado em: 2012-11
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4. Investigação do efeito neuroprotetor da atorvastatina em um modelo in vitro de toxicidade induzida pelo peptídeo ¿-amiloide
Alzheimer¿s disease is an age-related neurodegenerative disorder characterized by progressive memory loss, inability to perform the activities of daily living and personality changes. AD is characterized histopathologically by the presence of senile plaques, neurofibrillary tangles, synapse loss and neuronal death. Moreover, it is now recognized that neuroi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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5. Efeitos da alfa-sinucleína na modulação da atividade do fator de transcrição nuclear kB em células SH-SY5Y. / Activation of trasnscription fator kB induced by alpha-synuclein in SH-SY5Y cells.
Parkinsons Disease (PD) is a neurodegenerative disease. The characteristics and symptoms are well defined; nevertheless its etiology remains unknown. The sporadic PD is characterized by the presence of Lewy Body (aggregate of proteins) inside the neurons. Alpha-synuclein is a soluble protein present in the pre synaptic terminal of neurons. Evidences suggest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2011
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6. Amplificação sináptica e interações não lineares na arborização dendrítica de modelos de motoneurônios / Synapti Amplication and Nonlinearities interations in the dendritics tree of motoneurons models
A partir de modelos de motoneurônios (MN) de geometria e estrutura complexa e capacidade de reproduzir as características de um motoneurônio real, este trabalho tem como objetivos verificar as diferenças funcionais entre sinapses proximais e distais, investigar as interações não lineares de ativações sinápticas e estudar a influência dos canais pe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/04/2010
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7. Urinary proteomics evaluation in interstitial cystitis/painful bladder syndrome: a pilot study
PURPOSE: Interstitial cystitis/painful bladder syndrome (IC/PBS) is characterized by chronic pain, pressure and discomfort felt in the pelvis or bladder. An in-depth shotgun proteomics study was carried out to profile the urinary proteome of women with IC/PBS to identify possible specific proteins and networks associated with IC/PBS. MATERIALS AND METHODS: U
International braz j urol. Publicado em: 2010-08
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8. Amplificação sináptica e interações não lineares na arborização dendrítica de modelos de motoneurônios / Synapti Amplication and Nonlinearities interations in the dendritics tree of motoneurons models
A partir de modelos de motoneurônios (MN) de geometria e estrutura complexa e capacidade de reproduzir as características de um motoneurônio real, este trabalho tem como objetivos verificar as diferenças funcionais entre sinapses proximais e distais, investigar as interações não lineares de ativações sinápticas e estudar a influência dos canais pe
Publicado em: 2010
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9. The brain decade in debate : I. Neurobiology of learning and memory
This article is a transcription of an electronic symposium in which some active researchers were invited by the Brazilian Society for Neuroscience and Behavior (SBNeC) to discuss the last decade’s advances in neurobiology of learning and memory. The way different parts of the brain are recruited during the storage of different kinds of memory (e.g., short-
Publicado em: 2010
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10. Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update
Growing consistent evidence indicates that hypofunction of N-methyl-D-aspartate (NMDA) transmission plays a pivotal role in the neuropathophysiology of schizophrenia. Hence, drugs which modulate NMDA neurotransmission are promising approaches to the treatment of schizophrenia. The aim of this article is to review clinical trials with novel compounds acting o
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-11
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11. The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model
The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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12. NMDA receptor blockade alters the intracellular distribution of neuronal nitric oxide synthase in the superficial layers of the rat superior colliculus
Nitric oxide (NO) is a molecular messenger involved in several events of synaptic plasticity in the central nervous system. Ca2+ influx through the N-methyl-D-aspartate receptor (NMDAR) triggers the synthesis of NO by activating the enzyme neuronal nitric oxide synthase (nNOS) in postsynaptic densities. Therefore, NMDAR and nNOS are part of the intricate sce
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02