Tagsnps
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen’s disease) in Brazil
Leprosy remains prevalent in Brazil. ErbB2 is a receptor for leprosy bacilli entering Schwann cells, which mediates Mycobacterium leprae-induced demyelination and the ERBB2 gene lies within a leprosy susceptibility locus on chromosome 17q11-q21. To determine whether polymorphisms at the ERBB2 locus contribute to this linkage peak, three haplotype tagging sin
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-03
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2. Associação entre polimorfismos do gene da triptofano hidroxilase 2 e o transtorno obsessivo-compulsivo
OBJETIVO: Diversos estudos demonstram que o transtorno obsessivo-compulsivo apresenta considerável contribuição genética, com diversos genes candidatos tendo sido estudados por meio de estudos de associação. Como alterações do sistema serotonérgico estão associadas ao transtorno obsessivo-compulsivo, o gene da triptofano hidroxilase 2, enzima limit
Rev. Bras. Psiquiatr.. Publicado em: 11/03/2011
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3. Marcadores moleculares, imunológicos e genéticos das reações hansênicas / Molecular markers, genetic and immunological reactions of leprosy
As reações hansênicas do tipo 1 (RT1) e do tipo 2 (RT2) representam complicações no manejo clínico dos pacientes com hanseníase pois podem causar dano neural e conseqüentemente deformidades e incapacidades irreversíveis. Esta tese, apresentada sob a forma de artigo/manuscrito, abordou a identificação de potenciais marcadores para o diagnóstico e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/05/2009
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4. Marcadores moleculares, imunológicos e genéticos das reações hansênicas / Molecular markers, genetic and immunological reactions of leprosy
Type 1 (T1R) and Type 2 (T2R) leprosy reactions are complications in the clinical management of leprosy patients because they can lead to neural damage and impairment, resulting in irreversible deformities and disabilities. This thesis, presented as research article/manuscript has investigated potential markers for the diagnosis and prognosis of leprosy reac
Publicado em: 2009
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5. Impacto da miscigenaÃÃo na aplicaÃÃo do HapMap para a populaÃÃo brasileira avaliados nos genes PTPN22 e VDR
The PTPN22 and VDR genes are commonly associated to several autoimmune diseases and complex phenotypes related to bone metabolism. The association of some of those polymorphisms are ethnic-specific, and therefore, admixture population studies must be conditionally evaluated to these factors. The Brazilian population is considered the most heterogeneous in th
Publicado em: 2007
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6. Genetic susceptibility in leprosy: molecular analysis of HLA classroom II and classroom III. / Suscetibilidade Genética na Hanseníase:análise Molecular de HLA classe II &classe III.
Diversos estudos têm demonstrado a influência da variabilidade genética humana na capacidade de resposta ao M. leprae, agente etiológico causador da hanseníase. Através de diferentes técnicas a genética moderna tem contribuído para a determinação de regiões importantes associadas à doença, dentre elas o cromossomo 6p21, apontando principalmente
Publicado em: 2007
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7. Estudo de associação entre Síndrome de Tourette e genes da via Slit-Robo
Tourette syndrome (TS) is a neuropsichyatric disorder characterized by tics and familiar inheritance. Several research groups are investigating the genetic aspects of TS, however, frequently the findings are not replicated in subsequent studies. Study of gene Slit and trk-like family member 1 (SLITRK1) has shown correlation with TS in three non-related patie
Publicado em: 2006
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8. Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammation, and innate immunity, and several are mutated or have altered expression in non-Hodgkin lymphoma (NHL). To study the impact of genetic variation in caspases on NHL risk, we analyzed tag single nucleotide polymorphisms (SNPs) in 12 caspase and related genes in 3 popul
American Society of Hematology.
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9. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hanss⃞
We previously found that plasma RBP4 levels were strongly associated with metabolic syndrome components. This study aimed to determine whether RBP4 variants are associated with the metabolic syndrome components and plasma RBP4 levels, and to investigate whether the associations between plasma RBP4 and the metabolic syndrome components are causal. Five tagSNP
American Society for Biochemistry and Molecular Biology.