Tail Flick Test
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems
Abstract Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in i
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 19/01/2017
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2. Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent
Endogenous carbon monoxide (CO), which is produced by the enzyme heme oxygenase (HO), participates as a neuromodulator in physiological processes such as thermoregulation and nociception by stimulating the formation of 3′,5′-cyclic guanosine monophosphate (cGMP). In particular, the acute physical restraint-induced fever of rats can be blocked by inhibiti
Braz J Med Biol Res. Publicado em: 19/09/2014
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3. Antinociceptive effects of saccharose and aqueous extract of Cordyline dracaenoides kunth (uvarana) in experimental models after induction of hyperalgesia using capsaicin
RESUMO: OBJETIVO: Há evidância de que substâncias doces, tais como a sacarose podem acentuar as propriedades analgésicas dos opióides endógenos, com alívio da dor; sabe-se também Cordyline dracaenoides Kunth, vulgarmente conhecida como uvarana, é utilizada na medicina popular como anti-inflamatório e agente analgésico. O objetivo do presente estu
MedicalExpress (São Paulo, online). Publicado em: 2014-04
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4. Anti-nociceptive and anti-oedematogenic properties of the hydroethanolic extract of Sidastrum micranthum leaves in mice
Sidastrum micranthum (A. St.-Hil.) Fryxell, Malvaceae, grows in the northeastern region of Brazil, where the leaves of this species are traditionally used to treat coughs, bronchitis or asthma. Male Swiss mice (20-22 g) were tested in models of acute pain (acetic acid-induced abdominal writhing, tail flick and formalin test), oedema assessment test (paw oede
Rev. bras. farmacogn.. Publicado em: 2013-10
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5. Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening
The present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-05
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6. Involvement of NK-1 receptors of the basolateral and central nuclei of the amygdala in the defensive behavior of rats / Participação dos receptores NK-1 dos núcleos basolateral e central da amígdala no comportamento defensivo de ratos
A substantial body of evidence obtained in the last decade demonstrated that the Substance P (SP) is an important mediator of the affective and emotional behaviors. SP is a pro-aversive compound when microinjected within the dorsal periaqueductal gray (dPAG). These effects are mediated by the type 1 neurokininergic receptors (NK-1), since the defensive behav
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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7. Protective effect of oryzanol isolated from crude rice bran oil in experimental model of diabetic neuropathy
Several studies have implicated the involvement of poor glycemic control and oxidative/nitrosative stress in the development of diabetic neuropathic pain, an important microvascular complication affecting more than 50% of diabetic patients. However, lack of understanding of the underlying etiology, development of tolerance, inadequate relief and possible tox
Rev. bras. farmacogn.. Publicado em: 06/09/2012
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8. Assessment of biomedical and pharmacological activities of sea anemones Stichodactyla mertensii and Stichodactyla gigantea from Gulf of Mannar Biosphere Reserve, southeast coast of India
Cnidarians comprise an old and diverse animal phylum, and possess a wide variety of biologically active substances. Sea anemones contain a diversity of interesting biologically active compounds including some potent toxins. In the present work, the sea anemones Stichodactyla mertensii and Stichodactyla gigantea, collected from the Mandapam coast, are charact
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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9. Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts
Vitex cymosa Bertero ex Spreng., Lamiaceae, is found in Central and Amazon regions of Brazil, where it is popularly used as antirheumatic. Extracts from the leaves of V. cymosa were tested in analgesia models such as abdominal contortions induced by acetic acid and formalin to test peripheral analgesia; as well as the tail flick and hot plate models, to test
Revista Brasileira de Farmacognosia. Publicado em: 02/09/2011
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10. Atividade Antinociceptiva, em dores agudas, de um novo fator extraído da secreção cutânea de Rhinella jimi (Amphibia Anura) / Antinociceptive activity in acute pain, a new factor extracted from the skin secretion of Rhinella jimi (Amphibia - Anura)
Pain control has been an important focus of health for a long time. The ideal analgesic should be powerful, promoting maximum pain relief, but must submit a minimum adverse symptoms. The opioid agonists are used in treatment of intense acute pains and chronic pains in terminal patients, although they present important side effects, such as constipation, resp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/12/2009
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11. Influência do ambiente aversivo na resposta nociceptiva de ratos : um estudo sobre o papel de receptores opióides e canabinóides
Em situações ameaçadoras de natureza inata ou aprendida, animais exibem um conjunto de comportamentos defensivos espécie-específicos, tais como alterações autonômicas, fuga, luta e antinocicepção. A exposição de camundongos ao labirinto em cruz elevado aberto (LCEa: quatro braços abertos), uma situação aversiva, induz antinocicepção de alta
Publicado em: 2009
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12. TOXICIDADE AGUDA E EFEITOS ANALGÉSICO E DEPRESSOR DO EXTRATO AQUOSO OBTIDO DAS FOLHAS DE Pluchea sagittalis (Lam.) Cabrera (quitoco).
The Pluchea sagittalis (Lam) Cabreira, Family Asteraceae, is a plant of the Atlantic Reainforest used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The objective of this dissertation work was to study the possible effects of the aqueous extract of Pluchea sagittalis (Lam) Cabreira, on the Central
Publicado em: 2007