Telomeric Proteins
Mostrando 1-12 de 130 artigos, teses e dissertações.
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1. DNA damage in the kidney tissue cells of the fish Rhamdia quelen after trophic contamination with aluminum sulfate
Abstract Even though aluminum is the third most common element present in the earth's crust, information regarding its toxicity remains scarce. It is known that in certain cases, aluminum is neurotoxic, but its effect in other tissues is unknown. The aim of this work was to analyze the genotoxic potential of aluminum sulfate in kidney tissue of the fish Rham
Genet. Mol. Biol.. Publicado em: 24/11/2015
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2. Biochemical and molecular characterization of the Leishmania spp. telomerase reverse transcriptase component / Caracterização bioquimica e molecular do componente transcriptase reversa da telomerase de Leishmania spp
Telomeres are protein-DNA complexes that protect linear chromosomes from degradation, providing genomic stability. The telomeric sequences are G-rich and contain a 3 single-stranded region that protrudes toward the chromosome end. In Leishmania, the telomeric DNA is composed by the conserved 5 -TTAGGG-3 repeated sequence and it is replicated by telomerase. T
Publicado em: 2007
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3. Characterization of the in vivo telomeric single-strand binding proteins from Leishmania amazonensis / Caracterização de proteinas que se associam in vivo com a simples-fita telomerica de Leishmania amazonensis
ormado.
Publicado em: 2007
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4. Identificação e isolamento de proteinas que se ligam aos telomeros de Leishmania (L.) amazonensis / Identification and purification of Leishmania (L.) amazonensis telomeric proteins
A leishmaniose é uma doença parasitária que foi considerada pela Organização Mundial de Saúde como uma doença de Categoria 1, pois para a mesma não existem formas de controle, diagnóstico ou terapia eficientes. Os parasitas do gênero Leishmania (família Trypanosomatidae) são agentes etiológicos da leishmaniose e possuem cromossomos lineares com
Publicado em: 2007
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5. Identificação e caracterização de proteinas que se associam in vitro a fita telomerica rica em G de Leishmania (Leishmania) amazonensis / Identification and characterization of proteins that associate in vitro with the Leishmania (Leishmania) amazonensis G-rich telomeric strand
The chromosomal ends of Leishmania (Leishmania) amazonensis contain conserved 5 - TTAGGG-3 telomeric repeats, that are maintained by telomerase. Using Telomeric Repeat Amplification Protocol (TRAP) we detected telomerase activity in protein fractions purified from S100 and nuclear extracts. Protein complexes that associate in vitro with telomeric DNA sequenc
Publicado em: 2004
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6. Analise citogenetica, citoquimica e ultraestrutural da espermiogenese de especies de Physalaemus e Pseudopaludicola falcipes com enfase a caracterização taxonomica de Physalaemus biligonigerus e P. fuscomaculatus
The genus Physalaemus, belonging to the family Leptodactylidae, shows extensive polymorphism and an abundance of cryptic species. At least four species are currently recognized in this genus. In this work, we investigated some aspects of the cytogenetics and spermiogenesis of several species in this genus, with particular emphasis on P. fuscomaculatus and P.
Publicado em: 2000
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7. Dynamics of Protein Binding to Telomeres in Living Cells: Implications for Telomere Structure and Function
Telomeric proteins have an essential role in the regulation of the length of the telomeric DNA tract and in protection against end-to-end chromosome fusion. Telomere organization and how individual proteins are involved in different telomere functions in living cells is largely unknown. By using green fluorescent protein tagging and photobleaching, we invest
American Society for Microbiology.
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8. The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.
The yeast TTAGGG binding factor 1 (Tbf1) was identified and cloned through its ability to interact with vertebrate telomeric repeats in vitro. We show here that a sequence of 60 amino acids located in its C-terminus is critical for DNA binding. This sequence exhibits homologies with Myb repeats and is conserved among five proteins from plants, two of which a
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9. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2
The ends of linear chromosomes are capped by protein–DNA complexes termed telomeres. Telomere repeat binding factors 1 and 2 (TRF1 and TRF2) bind specifically to duplex telomeric DNA and are critical components of functional telomeres. Consequences of telomere dysfunction include genomic instability, cellular apoptosis or senescence and organismal aging. M
Oxford University Press.
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10. Targeting Assay To Study the cis Functions of Human Telomeric Proteins: Evidence for Inhibition of Telomerase by TRF1 and for Activation of Telomere Degradation by TRF2
We investigated the control of telomere length by the human telomeric proteins TRF1 and TRF2. To this end, we established telomerase-positive cell lines in which the targeting of these telomeric proteins to specific telomeres could be induced. We demonstrate that their targeting leads to telomere shortening. This indicates that these proteins act in cis to r
American Society for Microbiology.
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11. A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei.
We have identified a class of proteins that bind single-stranded telomeric DNA and are required for the nuclear organization of telomeres and/or telomere-associated proteins. Rlf6p was identified by its sequence similarity to Gbp1p, a single-stranded telomeric DNA-binding protein from Chlamydomonas reinhardtii. Rlf6p and Gbp1p bind yeast single-stranded G-st
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12. Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae.
Telomeric DNA in Saccharomyces is organized into a non-nucleosomal chromatin structure called the telosome that can be released from chromosome ends in soluble form by nuclease digestion (Wright, J. H., Gottschling, D. E. and Zakian, V. A. (1992) Genes Dev. 6, 197-210). The protein-DNA interactions of soluble telosomes were investigated by monitoring isolate