Terminal Schwann Cell
Mostrando 1-12 de 23 artigos, teses e dissertações.
-
1. Expression of the receiver for mannose in cells of Schwann and Schwannoma ST88-14. / Expressão do receptor para manose em células de Schwann e Schwannoma ST88-14.
The mannose receptor (MR) is a transmembrane glycoprotein that is expressed in several cell types but little or no information is available on Schwann cells (SC). We show that rodent SC in primary cultures of dissociated cells or explant nerve cultures and a human Schwannoma cell line (ST88-14) bind the exogenous MR ligand neoglycoprotein mannosyl/bovine ser
Publicado em: 2006
-
2. O oxido nitrico na plasticidade das celulas de Schwann terminais e dos terminais nervosos da junção neuromuscular
Músculos distróficos apresentam alterações no complexo distrofinaglicoproteínas, bem como ausência da enzima óxido nítrico sintase neuronal, associada a alterações na estrutura da junção neuromuscular. No presente trabalho, estudamos as respostas dos terminais nervosos e das células de Schwann terminais após lesão nervosa, na ausência de óxi
Publicado em: 2005
-
3. Neurally evoked calcium transients in terminal Schwann cells at the neuromuscular junction.
We examined the effects of motor-nerve stimulation on the intracellular Ca2+ levels of Schwann cells, the glial cells at the frog neuromuscular junction. Schwann cells, which were loaded with the fluorescent Ca2+ indicator fluo-3 and examined by confocal microscopy, showed a transient increase in free Ca2+ within a few seconds of the onset of tetanic stimula
-
4. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway
During development and nerve injury, complex interactions between glial cells and neurons are essential for establishing proper nerve function. Neurotrophins play multiple roles in the developing nervous system, including cell survival, growth, and differentiation. Here we show that migration of Schwann cells, isolated from sciatic nerves, is significantly e
National Academy of Sciences.
-
5. Cell death in the Schwann cell lineage and its regulation by neuregulin.
The development of Schwann cells, the myelin-forming glial cells of the vertebrate peripheral nervous system, involves a neonatal phase of proliferation in which cells migrate along and segregate newly formed axons. Withdrawal from the cell cycle, around postnatal days 2-4 in rodents, initiates terminal differentiation to the myelinating state. During this t
-
6. Expression of Toll-Like Receptor 2 on Human Schwann Cells: a Mechanism of Nerve Damage in Leprosy
Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surface of human Schwann cell line ST88-14 an
American Society for Microbiology.
-
7. Differential cell-specific location of Cav-1 and Ca2+-ATPase in terminal Schwann cells and mechanoreceptive Ruffini endings in the periodontal ligament of the rat incisor
Caveolae are involved in clathrin-independent endocytosis, transcytosis, signal transduction, and tumor suppression – all of which depend on their main constituent protein caveolin families. The periodontal Ruffini ending has been reported to develop a caveola-like structure on the cell membrane of both the axon terminals and Schwann sheaths, suggesting th
Blackwell Science Inc.
-
8. Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein
Specific mutations in some tumor suppressor genes such as p53 can act in a dominant fashion. We tested whether this mechanism may also apply for the neurofibromatosis type-2 gene (NF2) which, when mutated, leads to schwannoma development. Transgenic mice were generated that express, in Schwann cells, mutant NF2 proteins prototypic of natural mutants observed
Cold Spring Harbor Laboratory Press.
-
9. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration
During the development of the peripheral nervous system, Schwann cells, the myelin-forming glia, migrate along axons before initiating myelination. We previously demonstrated that endogenous neurotrophin-3 (NT3) acting through the TrkC tyrosine kinase receptor enhances migration of premyelinating Schwann cells. This signaling pathway is mediated by the c-Jun
National Academy of Sciences.
-
10. The sensory innervation of the nasal glabrous skin in the short-nosed bandicoot (Isoodon macrourus) and the opossum (Didelphis virginiana).
The glabrous skin at the anterior end of the snout of the short-nosed bandicoot and the American opossum was investigated by electron microscopy. In both species of animals, this region was lined by skin with broad epidermal pegs, innervated by three types of intraepidermal nerves. These were intraepidermal nerves which penetrated the epidermis up to the lev
-
11. A role for Pak protein kinases in Schwann cell transformation
Neurofibromatosis type 1 (NF1), a common autosomal dominant disorder caused by loss of the NF1 gene, is characterized clinically by neurofibromas and more rarely by neurofibrosarcomas. Neurofibromin, the protein encoded by NF1, possesses an intrinsic GTPase accelerating activity for the Ras proto-oncogene. Through this activity, it is a negative regulator of
The National Academy of Sciences.
-
12. A 21-kDa surface protein of Mycobacterium leprae binds peripheral nerve laminin-2 and mediates Schwann cell invasion
Nerve damage is the hallmark of Mycobacterium leprae infection, which results from M. leprae invasion of the Schwann cell of the peripheral nervous system. We have recently shown that the laminin-2 isoform, specially the G domain of laminin α2 chain, on the Schwann cell–axon unit serves as an initial neural target for M. leprae. However, M. leprae surface
The National Academy of Sciences.