Thrombomodulin
Mostrando 1-12 de 66 artigos, teses e dissertações.
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1. The involvement of endothelial mediators in leprosy
Leprosy is a chronic infectious disease that requires better understanding since it continues to be a significant health problem in many parts of the world. Leprosy reactions are acute inflammatory episodes regarded as the central etiology of nerve damage in the disease. The activation of endothelium is a relevant phenomenon to be investigated in leprosy rea
Mem. Inst. Oswaldo Cruz. Publicado em: 03/10/2016
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2. Low grade urothelial carcinoma mimicking basal cell hyperplasia and transitional metaplasia in needle prostate biopsy
ABSTRACT Purpose The vast majority of urothelial carcinomas infiltrating the bladder are consistent with high-grade tumors that can be easily recognized as malignant in needle prostatic biopsies. In contrast, the histological changes of low-grade urothelial carcinomas in this kind of biopsy have not been studied. Materials and Methods We describe the clini
Int. braz j urol.. Publicado em: 2016-04
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3. Avaliação de marcadores hemostáticos e pró-inflamatório na doença arterial coronariana
Cardiovascular diseases constitute the main cause of death in worldwide justifying a number of investigations on this matter. The present study aimed to investigate the association between hemostatic parameters and reactive C protein (CRP), and the coronary artery disease (CAD) severity in 123 patients submitted to coronary angiography scored in three groups
Publicado em: 2007
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4. Predictive value of the plasmatic levels of thrombomodulin in patients with intermittent claudication and critical ischemia in the lower limbs / "Valor preditivo da trombomodulina sérica em pacientes com claudicação intermitente e com isquemia crítica de membros inferiores"
A Trombomodulina é um marcador endotelial da doença aterosclerótica, e seu uso como preditor da doença arterial obstrutiva periférica (DAOP) deve ser comprovada. Avaliou-se 41 pacientes com claudicação intermitente e 40 com isquemia crítica. A Trombomodulina plasmática (TMp) foi quantificada em todos os pacientes, através de método imunoenzimátic
Publicado em: 2006
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5. Thrombomodulin is present in human plasma and urine.
Thrombomodulin is an endothelial cell membrane protein that is a cofactor required for the rapid activation of plasma protein C. We now report that plasma and urine of normal subjects contains a modified form of thrombomodulin that is soluble. The levels measured by radioimmunoassay were 292 +/- 60 ng thrombomodulin/ml plasma and 102 +/- 38 ng thrombomodulin
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6. Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin.
The effect of human thrombomodulin isolated from placenta on the procoagulant activity of thrombin was studied and compared to that of rabbit thrombomodulin. The isolated protein was proved to be thrombomodulin because a rabbit antibody against the isolated protein blocked protein C activation by thrombomodulin in solution and also blocked the protein-C-acti
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7. Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation.
Thrombomodulin is an endothelial cell surface glycoprotein that inhibits the procoagulant activities of thrombin and accelerates activation of the anticoagulant protein C. Because protein C deficiency is associated with cutaneous thrombosis, we investigated the expression of thrombomodulin in human skin. Thrombomodulin was detected by immunohistochemical sta
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8. Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin.
We have measured mRNA levels for thrombomodulin, an endothelial membrane cofactor for the activation of protein C by thrombin, in a mouse hemangioma cell line. Cycloheximide, an inhibitor of protein synthesis, increased levels of thrombomodulin mRNA, as measured in an S1 nuclease protection assay, to 2.5-4.0 times control levels. Thrombomodulin transcription
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9. Inhibition by human thrombomodulin of factor Xa-mediated cleavage of prothrombin.
Human thrombomodulin significantly inhibited the rate of prothrombin conversion to thrombin by Factor Xa in the presence of phospholipid or platelets, calcium, and Factor Va. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of 125I-prothrombin activation revealed that thrombomodulin reduced the rate of prothrombin activation but did not alter the cl
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10. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.
Elevated levels of plasma homocysteine are associated with both venous and arterial thrombosis. Homocysteine inhibits the function of thrombomodulin, an anticoagulant glycoprotein on the endothelial surface that serves as a cofactor for the activation of protein C by thrombin. The effects of homocysteine on thrombomodulin expression and protein C activation
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11. Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (pro-urokinase) by thrombomodulin.
The in vitro effects of thrombomodulin on the inactivation of single chain urokinase-type plasminogen activator (scu-PA) by thrombin were investigated by incubating scu-PA with varying concentrations of human thrombin, in both the absence and presence of soluble rabbit thrombomodulin. 50% inactivation of scu-PA occurred in 45 min at 160 ng/ml thrombin in the
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12. Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor.
We have isolated a partial-length cDNA for bovine thrombomodulin from a lambda gt11 bovine adrenal capillary endothelial cell expression library. This was accomplished by immunoscreening with rabbit anti-thrombomodulin IgG heteroantibody and then rescreening with the initial positive recombinant insert. The cDNA obtained was authenticated by showing that it