Transforming Growth Factor Beta1 Analysis
Mostrando 1-12 de 101 artigos, teses e dissertações.
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1. Immunohistochemical expression of TGF-β1 and MMP-9 in periapical lesions
Abstract The objective of this study was to evaluate the expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta (TGF-β1) in periapical lesion samples correlated with the intensity of the inflammatory infiltrate and thickness of the epithelial lining. Forty-five cases of periapical lesions (23 periapical granulomas and 22 radicu
Braz. oral res.. Publicado em: 03/07/2017
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2. Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-β1 levels in PDAC. In
Braz J Med Biol Res. Publicado em: 25/07/2016
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3. Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies
Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cance
Braz. arch. biol. technol.. Publicado em: 01/05/2015
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4. Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factor
Objective: The aim of this work was to demonstrate a possible relationship between anti-latency-associated peptide human latent transforming growth factor beta 1 (latent TGF-β1) expression in megakaryocytes and microvascular density in bone marrow biopsies from patients with essential thrombocythemia and primary myelofibrosis. Methods: Microvascular dens
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-10
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5. Fibrose muscular em camundongo mdx : efeitos do exercício físico e de agente anti-fibrótico / : Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-beta1 blocker
The mdx mouse is commonly used as a model to study Duchenne muscular dystrophy (DMD) however shows cycles of muscle regeneration and reduced fibrosis. The purposes of this study were (1) to induce muscle fibrosis through eccentric running exercise in mdx mice and (2) to verify the effects of suramin on muscle fibrosis. Six-month-old mdx (n=42) and control (C
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/02/2011
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6. Estudo dos efeitos do Mycobacterium leprae, seus componentes lipídicos e do TGF-b1 nas alterações da matriz extracelular neural / Study of the effects of Mycobacterium leprae, and their lipid components of the TGF-b1 changes in extracellular matrix neural
A fibrose neural é uma das causas de deformidades durante o curso crônico da hanseníase, a qual ainda é um grande problema de saúde pública mundial. A degeneração neural progride mesmo depois da cura do paciente e as células de Schwann (CS) estão envolvidas na degeneração e regeneração neural. A produção de citocinas pela CS parece estar rela
Publicado em: 2008
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7. Analise dos efeitos e dos mecanismos de ação do fator de crescimento transformante- beta 1, interferon gama e iclosporina A na transdiferenciação dos fibroblastos gengivais em miofibroblastos / Effects of transforming growth factor- beta 1, interferon gamma and cyclosporin A on transdifferentiation of gingival fibroblasts in myofibroblasts
Myofibroblasts are the main cellular type involved in extracellular matrix deposition in fibrotic diseases. Relatively little is known about the underlying mechanisms that regulate myofibroblast emergence (transdifferentiation), however the regulatory cytokine transforming growth factor-beta 1 (TGF- beta 1) has been traditionally considered an inducer of the
Publicado em: 2007
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8. Myofibroblasts are frequent in the stroma and invasive front of oral squamous cell carcinomas where they control the tumoral behavior by stimulating cellular proliferation and matrix metalloproteinase 2 activity of the tumor cells / Miofibroblastos são frequentes no estroma e no fronte invasivo dos carcinomas espinocelulares orais onde controlam o comportamento tumoral por estimular a proliferação celular e a atividade da metaloproteinase de matriz 2 das celulas tumorais
Myofibroblasts are characterized by the expression of elevated amounts of growth factors, proteases and extracellular matrix, which may influence the tumor progression. Recent studies have detected myofibroblasts in the stroma of several tumors, including those of breast, kidney, liver, bladder, colon and prostate, being the presence of those cells associate
Publicado em: 2007
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9. Análise do perfil de expressão gênica de sarcomas de partes moles de extremidades de adultos submetidos a quimioterapia neoadjuvante com doxorrubicina e ifosfamida / Gene expression profile of adult extremity soft tissue sarcomas submitted to neoadjuvant chemotherapy with doxorubicin and ifosphamide
INTRODUÇÃO: A cirurgia associada à radioterapia proporciona altas taxas de preservação de membros e de controle local em sarcomas de partes moles de extremidade de adultos, mas ainda apresenta elevadas taxas de complicações locais e de metástases à distância. O valor da quimioterapia adjuvante ou neoadjuvante ainda é controverso e objeto de invest
Publicado em: 2007
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10. "Determinação do perfil de expressão dos RNAs mensageiros da família das Smads e dos componentes do complexo AP-1 em carcinoma de célula escamosa de cabeça e pescoço" / Smads and AP-1 messenger RNA expression pattern in Head and Neck Squamous Cell Carcinoma
Smad and AP1 messenger RNA expression may underlie disruptions affecting TGFb signaling in head and neck squamous cell carcinoma (HNSCC). Analysis of Smads1-8 mRNA expression by RPA has shown Smad expression is globally increased in tumor as compared to adjacent normal tissue. Kaplan Meier survival curves and multivariate analysis revealed that Smad6 positiv
Publicado em: 2005
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11. Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex.
Growth factor-independent 32D-src and 32D-abl cell lines, established by infecting the interleukin-3-dependent myeloid precursor cell line (32D-123) with retroviruses containing the src or abl oncogene, were used to study transcriptional regulation of transforming growth factor beta 1 (TGF-beta 1) mRNA. Analysis of different TGF-beta 1 promoter constructs re
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12. Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.
Transin is a transformation-associated gene which is expressed constitutively in rat fibroblasts transformed by a variety of oncogenes and in malignant mouse skin carcinomas but not benign papillomas or normal skin. It has been demonstrated that, in nontransformed Rat-1 cells, transin RNA expression is modulated positively by epidermal growth factor (EGF) an