Transgenetic
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Stable silencing of β-lactoglobulin (BLG) gene by lentivirus-mediated RNAi in goat fetal fibroblasts
β-lactoglobulin (BLG), a dominant allergen in goat milk, is difficult to remove by traditional biochemical methods. Its elimination from goat milk by genetic modification therefore poses a major challenge for modern goat breeders. A shRNA targeting BLG mRNA with high interference efficiency was identified, with which lentiviral vectors were used for mediati
Genetics and Molecular Biology. Publicado em: 05/07/2012
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2. Algoritomos transgenéticos aplicados ao problema da árvore geradora biobjetivo
A Árvore Geradora Multiobjetivo é um problema de Otimização Combinatória NP-árduo. Esse problema possui aplicação em diversas áreas, em especial, no projeto de redes. Nesse trabalho, propõe-se uma solução para o problema em sua versão biobjetivo por meio de um Algoritmo Transgenético, denominado ATIS-NP. A Transgenética Computacional é uma t�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2011
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3. Algoritmo treansgenético na solução do problema do Caixeiro Viajante
The Traveling Purchaser Problem is a variant of the Traveling Salesman Problem, where there is a set of markets and a set of products. Each product is available on a subset of markets and its unit cost depends on the market where it is available. The objective is to buy all the products, departing and returning to a domicile, at the least possible cost defin
Publicado em: 2007
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4. Um estudo algorítmico de problemas logísticos na indústria de petróleo e gás natural / An algorithmic study of logistic problems on petroleum and natural gas industry
This work consists on the study of two important problems arising from the operations of petroleum and natural gas industries. The first problem the pipe dimensioning problem on constrained gas distribution networks consists in finding the least cost combination of diameters from a discrete set of commercially available ones for the pipes of a given gas netw
Publicado em: 2006
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5. Metodologia estatística na solução do problema do caixeiro viajante e na avaliação de algoritmos : um estudo aplicado à transgenética computacional
Os problemas de otimização combinatória têm envolvido um grande número de pesquisadores na busca por soluções aproximativas para aqueles, desde a aceitação de que eles são considerados insolúveis em tempo polinomial. Inicialmente, essas soluções eram focalizadas por meio de heurísticas. Atualmente, as metaheurísticas são mais utilizadas para
Publicado em: 2005
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6. Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
Conversion of the cellular isoform of prion protein (PrPC) into the scrapie isoform (PrPSc) involves an increase in the beta-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic studies argue that PrPC and PrPSc form a complex during PrPSc formation; thus, synthetic PrP peptides, which mimic the conformational pluralism
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7. Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans
There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(BoPrP) mice. These same mice were also highly susceptible to a new
The National Academy of Sciences.
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8. Prions
Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP). Bovine spongiform encephalopathy (BSE), scrapie of sheep, and Creutzfeldt�
The National Academy of Sciences.
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9. Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
Results of transgenetic studies argue that the scrapie isoform of the prion protein (PrPSc) interacts with the substrate cellular PrP (PrPC) during conversion into nascent PrPSc. While PrPSc appears to accumulate primarily in lysosomes, caveolae-like domains (CLDs) have been suggested to be the site where PrPC is converted into PrPSc. We report herein
The National Academy of Sciences of the USA.