Transgenic Animal
Mostrando 1-12 de 298 artigos, teses e dissertações.
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1. An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis
Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disease models was the development of gene editing technique
Braz J Med Biol Res. Publicado em: 25/04/2019
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2. From Gene Targeting to Genome Editing: Transgenic animals applications and beyond
RESUMOTecnologias de modificação do genoma são ferramentas poderosas para a biologia molecular e áreas afins. Avanços na transgênese animal e em tecnologias de edição do genoma durante as últimas três décadas permitiram interrogar de modo sistemático a função de genes, o que pode ajudar a compreender como o genoma influencia a fisiologia celula
An. Acad. Bras. Ciênc.. Publicado em: 2015-08
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3. 6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure
Impaired temporal control is symptomatic of several neurological disorders; recently, it has been implicated in schizophrenia. An animal model of schizophrenia using 6-hydroxydopamine (6-OHDA) infused to the medial pre-frontal cortex (mPFC) was employed to examine its effects on temporal control. Twelve rats were trained on a peak-interval procedure (PIP) un
Psychol. Neurosci.. Publicado em: 06/06/2014
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4. microRNAs and the mammary gland: a new understanding of gene expression
MicroRNAs (miRNAs) have been identified in cells as well as in exosomes in biological fluids such as milk. In mammary gland, most of the miRNAs studied have functions related to immunity and show alterations in their pattern of expression during lactation. In mastitis, the inflammatory response caused by Streptococcus uberis alters the expression of miRNAs t
Genet. Mol. Biol.. Publicado em: 25/10/2013
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5. Mensurações ultrassonográficas da cisterna da glândula mamária de caprino transgênico
Milk production of transgenic does was evaluated by ultrasound measurements of the mammary gland. Two Canindé goats, which were nine months of age were used in the trial, one non-transgenic or other transgenic for hG-CSF. For hormone-induced lactation, animals were given estradiol (0.25mg/kg, IM), progesterone (0.75mg/kg, IM), and prednisolone (0.4mg/kg, IM
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2012-04
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6. AVALIAÇÃO FETO-PLACENTÁRIA DE CAPRINOS TRANSGÊNICOS PARA O FATOR ESTIMULANTE DE COLÔNIAS DE GRANULÓCITOS HUMANO (hG-CSF) / FETO-PLACENTAL EVALUATION OF TRANSGENIC GOATS FOR STIMULATING FACTOR granulocyte colony HUMAN (hG-CSF)
O objetivo deste trabalho foi avaliar o desenvolvimento morfológico e morfométrico de embriões e fetos caprinos transgênicos para o Fator Estimulante de Colônias de Granulócitos humano (hG-CSF), através do uso da ultrassonografia em tempo real. Foram utilizadas quatro cabras não transgênicas (NT) gestantes após fertilização usando um macho transg
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/12/2011
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7. Modelos para a produção de eritropoietina recombinante humana in vivo e in vitro com vetores plasmideais em ovinos / Models for the production of human recombinant erythropoietin in vivo and in vitro with plasmidial vectors in ovine
Some post-translational modifications are necessary for the production of biopharmaceutical proteins, such as recombinant human erythropoietin (rhEPO), with a good specific action and a high biological activity. These modifications are obtained only by bioreactors based on eukaryotic cell as mammary cells. Bioreactors, in vivo or in vitro, with this kind of
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2011
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8. CAPRINOS FUNDADORES TRANSGÊNICOS PARA O FATOR ESTIMULANTE DE COLÔNIAS DE GRANULÓCITOS HUMANO (hG-CSF): PARÂMETROS LEUCOCITÁRIOS E BIOQUÍMICOS ATÉ OS 285 DIAS DE IDADE / TRANSGENIC GOATS FOR FOUNDERS stimulating factor human granulocyte colony (hG-CSF): Leukocyte AND BIOCHEMICAL PARAMETERS TO THE 285 DAYS OF AGE
Human granulocyte colony-stimulating factor (hG-CSF) has been used as a hematopoietic growth factor due to its efficacy against neutropenia and chemotherapy-induced leucopenia. This project was approved by the Ethics Committee for Animal Use (CEUA-UECE, n 12/2005) and the National Technical Commission on Biosafety (CTNBIO, CQB n 0228/2006). Our group obtaine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/01/2011
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9. Production of recombinant proteins in milk of transgenic and non-transgenic goats
Among all the transgenic mammalians produced so far, goats have represented an excellent model of transgenesis when considering the factors such as the market demand for protein, volume of milk produced per lactation and reproductive rate. Various recombinant proteins have been obtained from the transgenic and non-transgenic goats, and among these, human ant
Brazilian Archives of Biology and Technology. Publicado em: 2011-10
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10. Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles (containing hyperphosphorylated Tau protein), along with neu
Clinics. Publicado em: 2011
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11. Characterization of storage proteins, amino acid profile and enzymes involved in lysine metabolism in genetic modified barley (Hordeum vulgare L.) / Caracterização de proteínas de reserva, perfil de aminoácidos e enzimas envolvidas no metabolismo de lisina em cevada (Hordeum vulgare L.) geneticamente modificada
Cereals represent an important source of protein to human food and animal feed. However, they are characterized by low nutritional quality of proteins due to the unbalanced composition of amino acids, caused by the excess of the amino acids proline and glutamine and deficiency of lysine, threonine and tryptophan. The prolamin storage proteins constitute 50%
Publicado em: 2011
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12. Expressão do growth and differentiation factor 9 (GDF9) e bone morphogenetic protein 15 (BMP15) in vitro e seu efeito no processo de luteinização em células da granulosa bovinas / Expression of growth and differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) and their effect on in vitro luteinization of bovine granulosa cells
Os sistemas de cultivo de células da granulosa vêm se desenvolvendo com o intuito de assemelhar-se às condições esteroidogênicas encontradas in vivo no folículo ovariano. A remoção do ovócito resulta na luteinização espontânea das células somáticas foliculares, com alteração no padrão esteroidogênico, que também acontece quando estas cél
Publicado em: 2010