Tyrosine Hydroxylase Immunohistochemistry
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Protective effect of luteolin on the transgenic Drosophila model of Parkinson’s disease
In the present study we have studied the effect of 25, 50, 75 and 100 µM of luteolin on the transgenic Drosophila expressing human alpha synuclein. The doses of luteolin were established in diet and the PD flies were allowed to feed on it for 24 days. After 24 days of exposure the flies were assayed for climbing assay, oxidative stress markers, caspase-3 &
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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2. Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion
Frogs have been used as an alternative model to study pain mechanisms. Since we did not find any reports on the effects of sciatic nerve transection (SNT) on the ultrastructure and pattern of metabolic substances in frog dorsal root ganglion (DRG) cells, in the present study, 18 adult male frogs (Rana catesbeiana) were divided into three experimental groups:
Braz J Med Biol Res. Publicado em: 24/05/2013
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3. Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra
Neonatal Sprague-Dawley rats were randomly divided into normal control, mild hypoxia-ischemia (HI), and severe HI groups (N = 10 in each group at each time) on postnatal day 7 (P7) to study the effect of mild and severe HI on anxiety-like behavior and the expression of tyrosine hydroxylase (TH) in the substantia nigra (SN). The mild and severe HI groups were
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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4. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl- D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 μg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal
Publicado em: 2011
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5. Neonatal handling and the expression of immunoreactivity to tyrosine hydroxylase in the hypothalamus of adult male rats
Neonatal handling has long-lasting effects on behavior and stress reactivity. The purpose of the present study was to investigate the effect of neonatal handling on the number of dopaminergic neurons in the hypothalamic nuclei of adult male rats as part of a series of studies that could explain the long-lasting effects of neonatal stimulation. Two groups of
Publicado em: 2010
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6. O papel do sistema dopaminérgico nigroestriatal na neurobiologia do sono / The role of the dopaminergic nigrostriatal system in the sleep neurobiology.
Dopamine (DA) is critically involved in regulating neural processes responsible for complex movements and emotions. Alterations in central dopaminergic neurotransmission have been implicated in important neurological and psychiatric disorders such as Parkinsons disease (PD) and schizophrenia. In addition, DA has recently been recognized as instrumental in th
Publicado em: 2008
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7. Training induced effects on noradrenaline synthesis/storage within the skeletal muscle and renal arterioles in spontaneously hypertensive rats / Efeitos do treinamento físico sobre a síntese/armazenamento de noradrenalina em arteríolas musculares esqueléticas e renais de ratos hipertensos espontâneos
We investigated the effects of training (T) on tyrosine hydroxylase (TH) density in arterioles and adrenals (neuro-hormoral responses). Male SHR were submitted to treadmill T (55% of maximal capacity) or kept sedentary (S). After AP and HR recordings, rats were anesthetized and tissues (soleus, gastrocnemius red, gracilis = locomotor; temporalis = non-locomo
Publicado em: 2007
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8. Tirosyne hydroxilase as a marker of sympathetic drive within skeletal muscle and renal arterioles of normotensive rats: effects of physical training. / Tirosina hidroxilase como marcador da atividade simpática em artérias musculares esqueléticas e renais de ratos normotensos: efeitos do treinamento fisico.
Exercise training (T) does not reduce pressure in normotensive, but causes peripheral and central adjustments on cardiovascular system, mediated by autonomic nervous system. In this study we investigated whether T (55% maximal exercise capacity) is able to change vascular sympathetic drive to skeletal muscle (locomotor, non-locomotor), kidney and adrenals, u
Publicado em: 2007
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9. Neonatal handling and the expression of immunoreactivity to tyrosine hydroxylase in the hypothalamus of adult male rats
Neonatal handling has long-lasting effects on behavior and stress reactivity. The purpose of the present study was to investigate the effect of neonatal handling on the number of dopaminergic neurons in the hypothalamic nuclei of adult male rats as part of a series of studies that could explain the long-lasting effects of neonatal stimulation. Two groups of
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-09
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10. Tyrosine 3-hydroxylase in rat brain and adrenal medulla: hybridization histochemistry and immunohistochemistry combined with retrograde tracing.
Rat brain and adrenal gland were analyzed by hybridization histochemistry using an RNA probe complementary to mRNA for tyrosine 3-hydroxylase (TyrOHase; tyrosine 3-monooxygenase, EC 1.14.16.2), by immunohistochemistry using TyrOHase antiserum, and by retrograde tracing using the fluorescent compound Fast blue. Cell bodies in the ventral mesencephalon contain
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11. Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human.
The distribution of acidic (aFGF) and basic (bFGF) fibroblast growth factor mRNA and protein were examined in mesencephalon by immunohistochemistry, immunoblot analysis, in situ hybridization histochemistry, and RNA analysis. Coexistence of aFGF or bFGF with tyrosine hydroxylase protein in nigral cells was observed with immunohistochemistry. Both aFGF and bF
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12. Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.
Expression and regulation of the catecholamine-synthesizing enzymes phenylethanolamine N-methyltransferase (PNMTase; S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase, EC 2.1.1.28) and tyrosine hydroxylase [TyrOHase; tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] and the coexistin