Vaccine Vehicle
Mostrando 1-12 de 33 artigos, teses e dissertações.
-
1. REVs-Chi: um novo sistema particulado para encapsulação de macromoléculas terapêuticas / REVs-Chi: A new particulate system for encapsulation of therapeutic macromolecules
A quitosana (Chi), a (1-4)-amino-2-desoxi-Ò-glicana, e a forma desacetilada da quitina, um polissacarideo das conchas de crustaceos. As suas caracteristicas unicas como a carga positiva, biodegradabilidade, biocompatibilidade, atoxicidade e estrutura rigida fazem com que esta macromolecula seja ideal para uso como sistema oral de entrega de vacinas. Foram p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2009
-
2. Study of the vaccine potencial of proteins from Schistosoma mansoni using atenuated recombinant salmonellas as vehicle for antigen presentation to the host / Estudo do potencial vacinal de proteínas de Schistosoma mansoni utilizando salmonelas atenuadas recombinantes como veículo para apresentação de antígenos ao hospedeiro
Schistosomiasis is one of the most important endemic diseases in the world, with more than 200 million people infected in 76 countries. It is estimated that more than 600 million people live in endemic areas. In 2003 extensive data from the transcriptome of Schsitosoma mansoni was made available. The information on the encoded proteins allowed the analysis o
Publicado em: 2009
-
3. Development of a new vaccine approach against hemolytic uremic syndrome using genetically modified Bacillus subtilis strain expressing Stx2 EHEC toxin. / Desenvolvimento de uma nova estratégia vacinal contra síndrome hemolítica urêmica utilizando linhagens geneticamente modificadas de Bacillus subtilis capazes de expressar a toxina Stx2 de EHEC.
The Hemolytic Uremic Syndrome (HUS) is the main disease associated with infections with Shiga toxin (Stx) - producing Escherichia coli strain and no effective vaccine or treatment exist. The Stx toxin consist of an enzymatically active A subunit and a pentameric B subunit responsible toxin binding to host cells. In this work we propose the use of Bacillus su
Publicado em: 2008
-
4. Expressão do gene lack de leishmania amazonesis em plantas de alface (lactuca sativa l.).
Leishmaniose is an infectious disease, not contagious. It is caused by the Leishmania protozoa. In addition, it is transmitted by the bite of an insect. Also known as Baurus ulcer and bad sore, leishmaniose, most of the times, is presented as an ulceration in a discovered area of the body. Commonly, where the bite occurred. Until this moment, there is not an
Publicado em: 2002
-
5. Use of Inoculated Eggs as a Vehicle for the Oral Rabies Vaccination of Red Foxes (Vulpes fulva)
The ERA vaccine strain of rabies virus propagated on continuous porcine kidney tissue culture cells (PK15) was inoculated into the yolk sac of embryonated chicken eggs for the purpose of oral vaccine distribution. Two inoculated eggs were subsequently fed to each of 12 serologically rabies-negative foxes. Six (50%) of the foxes developed demonstrable rabies
-
6. Immunogenicity of Purified Venezuelan Equine Encephalitis Virus Inactivated by Ionizing Radiation
Purified and concentrated Venezuelan equine encephalitis (VEE) virus derived from tissue cultures, rendered noninfectious by ionizing radiation with retention of in vitro serological activity, also retained a high level of immunogenicity. In mice, fluid vaccines afforded excellent protection against lethal challenge with homologous Trinidad strain VEE virus.
-
7. In vitro gene transfer using human papillomavirus-like particles.
Recombinant papillomavirus-like particles have recently been shown to be highly effective for the prevention of papillomavirus infections and associated tumors, and a virus-like particle-based vaccine against the most prevalent HPV causing genital infection in humans will be developed in the near future. Another use of these virus-like particles may lie in g
-
8. Molecular Cloning and Sequencing of the Circumsporozoite Protein Gene from Plasmodium falciparum Strain FCC-1/HN and Expression of the Gene in Mycobacteria
Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used as a live bacterial vaccine to immunize more than 2 billion people against tuberculosis. In an attempt to use this vaccine strain as a vehicle for protective antigens, the Plasmodium falciparum gene from strain FCC-1/HN encoding circumsporozoite protein (CSP) was amplified from the P. falcipar
American Society for Microbiology.
-
9. Heterologous Expression of an Immunogenic Pneumococcal Type 3 Capsular Polysaccharide in Lactococcus lactis
In order to develop a new system for the analysis of capsular biosynthetic pathways we have explored the possibility of expressing type 3 capsular polysaccharide (CPS) from the pathogen Streptococcus pneumoniae in Lactococcus lactis, an unencapsulated lactic acid bacterium being developed as a vaccine delivery vehicle for mucosal immunization. Only three of
American Society for Microbiology.
-
10. Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle.
The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-ty
-
11. Induction of Protective Immunity against Chlamydia trachomatis Genital Infection by a Vaccine Based on Major Outer Membrane Protein–Lipophilic Immune Response-Stimulating Complexes
The significance of delivery systems in modern vaccine design strategies is underscored by the fact that a promising vaccine formulation may fail in vivo due to an inappropriate delivery method. We evaluated the immunogenicity and efficacy of a candidate vaccine comprising the major outer membrane protein (MOMP) of Chlamydia trachomatis delivered with the li
American Society for Microbiology.
-
12. Erysipelothrix rhusiopathiae YS-1 as a Live Vaccine Vehicle for Heterologous Protein Expression and Intranasal Immunization of Pigs
We have developed a system in which a foreign antigen is delivered and expressed on the surface of an attenuated strain of Erysipelothrix rhusiopathiae YS-1 and have examined the ability of a such recombinant E. rhusiopathiae strain to function as a mucosal vaccine vector. The C-terminal portion, including two repeat regions, R1 and R2, of the P97 adhesin of
American Society for Microbiology.