Wnt Signalling Pathway
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Análise de genes diferencialmente expressos nas vias de sinalização (Hedgehog e Wnt) em carcinomas basocelulares humanos
Hedgehog (HH) and Wingless-Int (Wnt) signaling pathway are related to the process of cellular proliferation, differentiation, angiogenesis, matrix remodeling and homeostasis of stem cells. Over the years, several mutations in HH signaling pathway have been identified, including the loss of function mutations in ptch1 and the gain of function mutations in smo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/04/2012
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2. The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/β-catenin signalling
Frizzled receptors are components of the Wnt signalling pathway, but how they activate the canonical Wnt/β-catenin pathway is not clear. Here we use three distinct vertebrate frizzled receptors (Xfz3, Xfz4 and Xfz7) and describe whether and how their C-terminal cytoplasmic regions transduce the Wnt/β-catenin signal. We show that Xfz3 activates this pathway
Oxford University Press.
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3. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer. We show here that the JNK MAP kinase pathway and one of its most important substrates, the AP-1 transcription factor c-Jun, modulates Wnt signalling strength in the intestine. Transgenic gut-specific augmentation of JNK signalling stimulated progenitor cell prolifer
Nature Publishing Group.
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4. Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.
The Drosophila gene product Wingless (Wg) is a secreted glycoprotein and a member of the Wnt gene family. Genetic analysis of Drosophila epidermal development has defined a putative paracrine Wg signalling pathway involving the zeste-white 3/shaggy (zw3/sgg) gene product. Although putative components of Wg- (and by inference Wnt-) mediated signalling pathway
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5. Activation of Wnt/β-catenin signalling pathway induces chemoresistance to interferon-α/5-fluorouracil combination therapy for hepatocellular carcinoma
Type I IFN receptor type 2 (IFNAR2) expression correlates significantly with clinical response to interferon (IFN)-α/5-fluorouracil (5-FU) combination therapy for hepatocellular carcinoma (HCC). However, some IFNAR2-positive patients show no response to the therapy. This result suggests the possibility of other factors, which would be responsible for resist
Nature Publishing Group.
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6. Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK
Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC fu
Nature Publishing Group.
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7. The opposing roles of Wnt-5a in cancer
Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to transform cells or signal through the canon
Nature Publishing Group.
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8. The kinase TNIK is an essential activator of Wnt target genes
Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/β-catenin-activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/β-catenin transcriptional programme and tumourigenesis. The mechanisms by which TCF4/β-cate
Nature Publishing Group.
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9. The adenomatous polyposis coli protein.
Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role i
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10. Pontin52 and Reptin52 function as antagonistic regulators of β-catenin signalling activity
In Wnt-stimulated cells, β-catenin becomes stabilized in the cytoplasm, enters the nucleus and interacts with HMG box transcription factors of the lymphoid-enhancing factor-1 (LEF-1)/T-cell factor (TCF) family, thereby stimulating the transcription of specific target genes. We recently identified Pontin52 as a nuclear protein interacting with β-catenin and
Oxford University Press.
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11. All Tcf HMG box transcription factors interact with Groucho-related co-repressors
Tcf/Lef family transcription factors are the downstream effectors of the Wingless/Wnt signal transduction pathway. Upon Wingless/Wnt signalling, β-catenin translocates to the nucleus, interacts with Tcf (1–3) and thus activates transcription of target genes (4,5). Tcf factors also interact with members of the Groucho (Grg/TLE) family of transcriptio
Oxford University Press.
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12. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1
ILKAP, a protein serine/threonine (S/T) phosphatase of the PP2C family, was isolated in a yeast two-hybrid screen baited with integrin-linked kinase, ILK1. Association of ILK1 and ILKAP was independent of the catalytic activity of either partner, as assayed in co-precipitation and two-hybrid experiments. Condi tional expression of ILKAP in HEK 293 cells res
Oxford University Press.