Yohimbine
Mostrando 1-12 de 107 artigos, teses e dissertações.
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1. Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats
Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of hemorrhage/resuscitation (HS) and subsequent endotoxemia. E
Braz J Med Biol Res. Publicado em: 25/02/2019
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2. Antidiarrheal effect of extract from the bark of Combretum leprosum in mice
Abstract This study investigated the effects of the ethanolic extract from the bark of Combretum leprosum (ECL) on intestinal transit and castor-oil induced diarrhea in mice. The oral administration of ECL (750 and 1000 mg/kg) slowed intestinal transit (ID50 of 455 mg/kg). The ECL (250-1000 mg/kg) reduced castor-oil induced diarrhea, in a time- and dose-depe
An. Acad. Bras. Ciênc.. Publicado em: 17/12/2018
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3. The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury
Abstract Purpose: To investigate the effect of dexmedetomidine (Dex) in a rat ex vivo lung model of ischemia-reperfusion injury. Methods: An IL-2 ex vivo lung perfusion system was used to establish a rat ex vivo lung model of ischemia-reperfusion injury. Drugs were added to the perfusion solution for reperfusion. Lung injury was assessed by histopathologic
Acta Cir. Bras.. Publicado em: 2018-01
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4. Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves
ABSTRACT Muntingia calabura L., Muntingiaceae, is a medicinal plant for various pain-related diseases. The aims of the present study were to determine the antinociceptive profile and to elucidate the possible mechanisms of antinociception of petroleum ether partition obtained from crude methanol extract of M. calabura leaves using various animal models. The
Rev. bras. farmacogn.. Publicado em: 2016-08
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5. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system
Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H
Braz J Med Biol Res. Publicado em: 07/11/2014
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6. Evidence for the involvement of peripheral β-adrenoceptors in delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats
Dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At) delay liquid gastric emptying (GE) in rats. We evaluated adrenergic participation in this phenomenon in a study in male Wistar rats (250-300 g) pretreated subcutaneously with guanethidine (GUA), 100 mg·kg−1·day−1, or vehicle (V) for 2 days before experimental treatments. Other groups of animals
Braz J Med Biol Res. Publicado em: 27/09/2013
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7. InvestigaÃÃo da aÃÃo central do carvacrol em modelos de ansiedade, depressÃo e convulsÃo em camundongos e possÃveis mecanismos farmacolÃgicos envolvidos. / Investigation of central actions of carvacrol in animal models of anxiety, depression and convulsion in mice and possible pharmacological mechanisms involved.
Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of anxiety, depression, sedation and convulsion, such as, elevated plus maze (EPM), open field, rota
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/01/2010
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8. Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eich
Previous studies on Combretum leprosum, a tree growing in the Northeastern states of Brazil, have shown antinociceptive effects of the ethanol extract of its leaves and bark, but studies examining its constituents are rare. The objective of this study was to evaluate the antinociceptive effect of the hydroalcoholic fraction (HF) of one of its constituents, t
Braz J Med Biol Res. Publicado em: 2010-12
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9. Protective mechanism of agmatine pretreatment on RGC-5 cells injured by oxidative stress
Agmatine has neuroprotective effects on retinal ganglion cells (RGCs) as well as cortical and spinal neurons. It protects RGCs from oxidative stress even when it is not present at the time of injury. As agmatine has high affinity for various cellular receptors, we assessed protective mechanisms of agmatine using transformed RGCs (RGC-5 cell line). Differenti
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
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10. The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats
OBJECTIVE: The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats. METHODS: First, amitriptyline was administered intraperitoneally (i.p.) at doses of 20, 40 and 80 mg kg-1, 30 min before subplantar injection of carrageenan. Second, amitriptyline was gi
Clinics. Publicado em: 2010
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11. Efeito do Óleo Essencial do Croton sonderianus Muell. Arg. sobre o Trato Gastrointestinal. / Effect of Essential Oil of Croton sonderianus Muell. Arg. on the Gastrointestinal Tract.
Croton sonderianus, popularly known as Marmeleiro preto, present description of various medicinal properties, as actions diuretic, digestive e antimicrobial. In popular medicine is reputed per os, for the stomach ache, uterine bleeding, and in the control of vomitions and diarrhea. The present study, the essential oil of Croton sonderianus (OECson) evaluated
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/01/2008
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12. Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
Harmane has been proposed for the treatment of epilepsy, AIDS and leshmaniosis. Its room-temperature phosphorescence was induced using either AgNO3 or TlNO3, enabling absolute limits of detection of 0.12 and 2.4 ng respectively, with linear dynamic ranges extending up to 456 ng (AgNO3) and 911 ng (TlNO3). Relative standard deviations around 3% were observed
Química Nova. Publicado em: 2008