Zap 70 Protein
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. T cell receptor signaling pathway is overexpressed in CD4 + T cells from HAM/TSP individuals
ABSTRACT Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+ T cells activation appears to play a key role on HTLV-1 infection. Here we investigated the expression of genes associated to T cell activation CD3e molecule, epsi
Braz J Infect Dis. Publicado em: 2015-12
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2. Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. A better understanding of the biology, genetics and molecular mechanisms of gastric cancer would be useful in developing novel targeted approaches
Genetics and Molecular Biology. Publicado em: 13/07/2012
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3. Perfil ClÃnico e Laboratorial dos Pacientes com Leucemia Linfoide CrÃnica Atendidos no ServiÃo de Hematologia e Hemoterapiado HUWC-HEMOCE / Clinical and Laboratorial Profile of Patients with Chronic Lymphocytic Leukemia admitted at the hematology and hemotherapy service of the University Hospital Walter CantÃdio (HUWC) and Hemotherapy and Hematology Center of Cearà (HEMOCE).
A leucemia linfocÃtica crÃnica (LLC) à a leucemia mais freqÃente nos paÃses ocidentais, ocorrendo em cerca de 30% de todas as leucemias do adulto, acometendo principalmente a populaÃÃo acima de 65 anos de idade. à caracterizada pela proliferaÃÃo clonal de linfÃcitos tipo B CD5 positivos. Do ponto de vista epidemiolÃgico, raramente à vista entre
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/09/2009
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4. Serial Analysis of Gene Expression in CD8+ T-cells isolated from HTLV-1 infected individuals / Análise do perfil de expressão gênica em linfócitos T CD8+ isolados de pacientes infectados pelo HTLV-1
MALTA, T.M. Serial Analysis of Gene Expression in CD8+ T-cells isolated from HTLV-1 infected individuals. 2009. 137f. Dissertação de Mestrado. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo, Ribeirão Preto, 2009. Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus discovered and is related
Publicado em: 2009
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5. Interdomain B in ZAP-70 Regulates but Is Not Required for ZAP-70 Signaling Function in Lymphocytes
The protein tyrosine kinase ZAP-70 plays an important role in T-cell activation and development. After T-cell receptor stimulation, ZAP-70 associates with the receptor and is phosphorylated on many tyrosines, including Y292, Y315, and Y319 within interdomain B. Previously, we demonstrated that Y292 negatively regulates ZAP-70 function and that Y315 positivel
American Society for Microbiology.
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6. Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line
T-cell antigen receptor (TCR) engagement activates multiple protein tyrosine kinases (PTKs), including the Src family member, Lck, and the Syk-related PTK, ZAP-70. Studies in ZAP-70-deficient humans have demonstrated that ZAP-70 plays crucial roles in T-cell activation and development. However, progress toward a detailed understanding of the regulation and f
American Society for Microbiology.
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7. Mechanism of activation for Zap-70 catalytic activity.
There is a growing body of evidence, including data from human genetic and T-cell receptor function studies, which implicate a zeta-associated protein of M(r) 70,000 (Zap-70) as a critical protein tyrosine kinase in T-cell activation and development. During T-cell activation, Zap-70 becomes associated via its src homology type 2 (SH2) domains with tyrosine-p
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8. The Oncogenic 70Z Cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells
T-cell receptor (TCR) engagement results in the activation of Src family (Lck and Fyn) and ZAP-70 protein tyrosine kinases, leading to tyrosine phosphorylation of multiple cellular substrates including the complex adapter protein c-Cbl. Moreover, Cbl is tyrosine phosphorylated upon engagement of growth factor receptors, cytokine receptors, and immunoreceptor
American Society for Microbiology.
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9. Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
The protein tyrosine kinase ZAP-70 plays an essential role in T-cell activation and development. After T-cell receptor stimulation, ZAP-70 is associated with the receptor and is phosphorylated on many tyrosine residues, including tyrosine 292 (Y-292), in the region between the C-terminal SH2 domain and the kinase domain (interdomain B). Here we show that a m
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10. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.
Stimulation of the T-cell antigen receptor (TCR) leads to tyrosine phosphorylation of a number of cellular proteins, including phospholipase C (PLC) gamma 1 and the TCR zeta chain. We describe here a 70-kDa tyrosine phosphoprotein (ZAP-70) that associates with zeta within 15 sec following TCR stimulation. The phosphorylation of ZAP-70 and its association wit
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11. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.
ZAP-70 is a protein tyrosine kinase (PTK) required for T-cell development and T-cell antigen receptor (TCR) function. ZAP-70 is associated with the phosphorylated antigen receptor and undergoes tyrosine phosphorylation following receptor activation. We demonstrate here that tyrosine phosphorylation of ZAP-70 results in an increase in its catalytic activity a
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12. Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.
ZAP-70 is a protein tyrosine kinase thought to play a critical role in T-cell receptor (TCR) signal transduction. During T-cell activation, ZAP-70 binds to a conserved signalling motif known as the immune receptor tyrosine activating motif (ITAM) and becomes tyrosine phosphorylated. To determine whether binding of ZAP-70 to the phosphorylated ITAM was able t